CAS 166108-71-0

8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid

Description:

8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid, commonly referred to as Fmoc-D-OAA, is a synthetic compound primarily used in peptide synthesis and as a protecting group for amino acids. This substance features a dioxaoctanoic acid backbone, which contributes to its solubility and stability in various solvents. The presence of the fluorenylmethoxycarbonyl (Fmoc) group allows for selective protection of the amino group, facilitating the stepwise assembly of peptides. Fmoc-D-OAA is characterized by its ability to undergo deprotection under mild basic conditions, making it advantageous in solid-phase peptide synthesis. Additionally, the compound exhibits good compatibility with various coupling reagents and can be utilized in the synthesis of bioactive peptides. Its structure includes both hydrophilic and hydrophobic regions, which can influence its interaction with biological systems. Overall, Fmoc-D-OAA is a valuable tool in the field of organic chemistry and biochemistry, particularly in the development of peptide-based therapeutics.

Formula: C₂₁H₂₃NO₆

InChI: InChI=1/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)

InChI key: InChIKey=XQPYRJIMPDBGRW-UHFFFAOYSA-N

SMILES: C(OC(NCCOCCOCC(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• (2-[2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Ethoxy]-Ethoxy)-Acetic Acid
• 1-(9H-Fluoren-9-Yl)-3-Oxo-2,7,10-Trioxa-4-Azadodecan-12-Oic Acid
• 1-(9H-Fuoren-9-Yl)-3-Oxo-2,7,10-Trioxa-4-Azadodecan-12-Oic Acid
• 12-(9H-Fluoren-9-yl)-10-oxo-3,6,11-trioxa-9-azadodecanoic acid
• 2,7,10-Trioxa-4-azadodecan-12-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-
• 2-[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid
• 2-[2-[2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)ethoxy]ethoxy]acetic acid
• 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-
• 8-(9-Fluorenylmethoxycarbonyl-Amino)-3,6-Dioxa-Octanoic Acid
• 8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid
• 8-(Fmoc-Amino)-3,6-Dioxa-Octanoic Acid
• 8-(Fmoc-amino)-3,6-dioxaoctanoic acid
• 8-Fluorenylmethoxycarbonylamino-3,6-Dioxaoctanoic Acid
• 9-Fluorenylmethoxycarbonyl-8-Amino-3,6-Dioxaoctanoic Acid
• Fmoc-Aeea-Oh
• Fmoc-Aeeac-Oh
• Fmoc-NH-PEG₂-CH₂COOH
• Fmoc-aeea
• Rarechem Em Wb 0032
• (2-[2-(Fmoc-Amino)-Ethoxy]-Ethoxy)-Acetic Acid
• FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID
• FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID
• FMOC-O2OC-OH
• 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren
• FMOC-MINI-PEG(TM)
• 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
• 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA
• 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID

8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid

CAS: 166108-71-0

Formula: C₂₁H₂₃NO₆

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 385.42

Ref: 3B-F0719

(2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%

CAS: 166108-71-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₁H₂₃NO₆

Purity: 95%

Molecular weight: 385.42

Ref: 02-H63641

Fmoc-AEEAc-OH

CAS: 166108-71-0

Hydrophilic heterobifunctional spacer useful to attach chromophores. Building block for the synthesis of spacers of defined length.

Formula: C₂₁H₂₃NO₆

Purity: 99.9%

Color and Shape: White

Molecular weight: 385.42

Ref: 01-4037914

Fmoc-8-amino-3,6-dioxaoctanoic acid

CAS: 166108-71-0

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Formula: C₂₁H₂₃NO₆

Purity: 99.61% - 99.89%

Color and Shape: White Crystal

Molecular weight: 385.4104

Ref: TM-T15304

{2[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid

CAS: 166108-71-0

{2[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid

Formula: C₂₁H₂₃NO₆

Purity: 98%

Color and Shape: White Solid-Powder

Molecular weight: 385.41041

Ref: 54-OR0969

[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid

CAS: 166108-71-0

Formula: C₂₁H₂₃NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 385.4104

Ref: IN-DA001WHY

Fmoc-8-amino-3,6-dioxaoctanoic acid

CAS: 166108-71-0

Fmoc-8-amino-3,6-dioxaoctanoic acid

Formula: C₂₁H₂₃NO₆

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 385.41

Ref: 54-BUP19698

Fmoc-AEEA-OH

CAS: 166108-71-0

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid

Formula: C₂₁H₂₃NO₆

Purity: 98%

Molecular weight: 385.41

Ref: IN-DG130882

Fmoc-mini-PEG Fmoc-8-Amino-3,6-Dioxaoctanoic Acid

CAS: 166108-71-0

Fmoc-mini-PEG Fmoc-8-Amino-3,6-Dioxaoctanoic Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), these types of compounds are more versatile as they have two different anchor points. Fmoc-mini-PEG Fmoc-8-Amino-3,6-Dioxaoctanoic Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules, and nanoparticles. It is enzyme-cleavable via β-glucuronidase, releasing the drug or payload in enzyme-rich environments.

Formula: C₂₁H₂₃NO₆

Purity: Min. 95%

Molecular weight: 385.42 g/mol

Ref: 3D-FXX-5521-PI

Fmoc-AEEA

CAS: 166108-71-0

This PEGylated Fmoc linker is used for controlled conjugation of biomolecules. The cleavage occurs under chemical or enzymatic conditions.

Formula: C₂₁H₂₃NO₆

Purity: Min. 97.5 Area-%

Color and Shape: Powder

Molecular weight: 385.41 g/mol

Ref: 3D-FF35496

Fmoc-Amino-3,6 dioxaoctanoic acid

CAS: 166108-71-0

Formula: C₂₁H₂₃NO₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 385.416

Ref: 10-F050302

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid

Controlled Product

CAS: 166108-71-0

Applications 8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
References Koskinen, A., et al.: Bioorg. Med. Chem. Lett., 5, 573 (1995)

Formula: C₂₁H₂₃NO₆

Color and Shape: Neat

Molecular weight: 385.41

Ref: TR-F603515