CAS 1668-13-9

Alanine p-nitroanilide

Description:

Alanine p-nitroanilide, with the CAS number 1668-13-9, is an organic compound that serves as a substrate in various biochemical assays, particularly in the study of proteolytic enzymes. It is characterized by its structure, which includes an alanine amino acid moiety linked to a p-nitroaniline group. This compound is typically a white to pale yellow crystalline solid, and it is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). The presence of the p-nitro group enhances its spectroscopic properties, allowing for UV-visible absorbance measurements, which are useful in analytical chemistry. Alanine p-nitroanilide is often employed in enzyme kinetics studies, particularly for serine proteases, due to its ability to release p-nitroaniline upon cleavage, which can be quantitatively measured. Safety precautions should be taken when handling this compound, as it may pose health risks if ingested or inhaled, and appropriate personal protective equipment should be used.

Formula: C₉H₁₁N₃O₃

InChI: InChI=1S/C9H11N3O3/c1-6(10)9(13)11-7-2-4-8(5-3-7)12(14)15/h2-6H,10H2,1H3,(H,11,13)/t6-/m0/s1

InChI key: InChIKey=PXFUDSMGEYRNNC-LURJTMIESA-N

SMILES: N(C([C@H](C)N)=O)C1=CC=C(N(=O)=O)C=C1

Synonyms:

• (2S)-2-Amino-N-(4-nitrophenyl)propanamide
• 2-Amino-4′-nitro-<span class="text-smallcaps">L</span>-propionanilide
• <span class="text-smallcaps">L</span>-Alanine 4-nitroanilide
• <span class="text-smallcaps">L</span>-Alanine p-nitroanilide
• <span class="text-smallcaps">L</span>-Alanyl p-nitroanilide
• Ala-4-nitroanilide
• Alanine-4-nitroanilide
• Alanine-p-nitroanilide
• L-Alanine-4-nitroanilide
• N-(4-nitrophenyl)-L-alaninamide
• N-α-<span class="text-smallcaps">L</span>-Alanine p-nitroanilide
• Propanamide, 2-amino-N-(4-nitrophenyl)-, (2S)-
• Propanamide, 2-amino-N-(4-nitrophenyl)-, (S)-
• Propionanilide, 2-amino-4′-nitro-, <span class="text-smallcaps">L</span>-
• Propionanilide, 2-amino-4′-nitro-, L-

H-Ala-pNA

CAS: 1668-13-9

A good substrate for aminopeptidase M (microsomal alanyl aminopeptidase).

Formula: C₉H₁₁N₃O₃

Purity: > 99%

Color and Shape: Light Yellow Powder

Molecular weight: 209.21

Ref: 01-4000210

H-Ala-pna

CAS: 1668-13-9

Formula: C₉H₁₁N₃O₃

Color and Shape: Solid

Molecular weight: 209.2019

Ref: IN-DA001WYQ

L-Alanine 4-nitroanilide

CAS: 1668-13-9

Molecular weight: 209.2

Ref: 7W-GM4243

H-ALA-PNA

CAS: 1668-13-9

Formula: C₉H₁₁N₃O₃

Purity: 97.0%

Molecular weight: 209.205

Ref: 10-F475263

Ala-pNA

CAS: 1668-13-9

Ala-pNA is a peptide hormone that is related to vasopressin and has been shown to be a potential drug target for renal cell cancer. In vitro studies have shown that Ala-pNA inhibits the growth of human leukemia cells and other carcinoma cell lines. The reduction in cell proliferation was due to the decrease in proteolytic activity, which was due to the inhibition of collagenase synthesis. This peptide hormone also inhibits protein synthesis, leading to decreased production of enzymes such as p-nitrophenyl phosphate synthase and sodium citrate synthase. A study on the use of this compound on rats with induced renal carcinoma showed that it had no toxicological effects.

Formula: C₉H₁₁N₃O₃

Purity: Min. 95%

Molecular weight: 209.2 g/mol

Ref: 3D-SAN-3068