CAS 167074-97-7

10-Oxo Docetaxel

Description:

10-Oxo Docetaxel, identified by its CAS number 167074-97-7, is a synthetic derivative of the natural product taxol (paclitaxel), which is known for its potent anti-cancer properties. This compound features a ketone functional group at the 10-position of the taxane ring structure, which alters its pharmacological profile compared to its parent compound. The presence of the oxo group can influence the compound's solubility, stability, and interaction with biological targets, potentially enhancing its efficacy against various cancer types. Like other taxanes, 10-Oxo Docetaxel functions primarily by inhibiting microtubule depolymerization, thereby disrupting mitotic spindle formation and leading to cell cycle arrest in the G2/M phase. This mechanism makes it a valuable candidate in cancer therapy, particularly for solid tumors. Additionally, its chemical stability and bioavailability are critical factors that determine its therapeutic potential and side effect profile. Further research is essential to fully understand its pharmacokinetics, toxicity, and overall effectiveness in clinical settings.

Formula: C₄₃H₅₁NO₁₄

InChI: InChI=1/C43H51NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30,32-33,35,46,48,53H,19-21H2,1-8H3,(H,44,52)/t26?,27-,28+,30-,32?,33-,35?,41+,42-,43+/m0/s1

6-Oxo Docetaxel

CAS: 167074-97-7

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₃H₅₁NO₁₄

Color and Shape: White Powder

Molecular weight: 805.33096

Ref: 45-1A06230

(2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]

CAS: 167074-97-7

(2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]

Formula: C₄₃H₅₁NO₁₄

Purity: 93.89%

Molecular weight: 805.86

Ref: 54-OR1128264

10-Oxo Docetaxel

CAS: 167074-97-7

Formula: C₄₃H₅₁NO₁₄

Purity: 93.89%

Color and Shape: Solid

Molecular weight: 805.8633

Ref: IN-DA007WC1

Docetaxel EP Impurity B

CAS: 167074-97-7

Formula: C₄₃H₅₁NO₁₄

Color and Shape: Pale Yellow Solid

Molecular weight: 805.87

Ref: 4Z-D-199

10-Oxo Docetaxel

CAS: 167074-97-7

10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.

Formula: C₄₃H₅₁NO₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 805.874

Ref: TM-TQ0142

10-Deoxy-10-oxodocetaxel

CAS: 167074-97-7

Color and Shape: Neat

Ref: 86-MM3396.06

Docetaxel EP Impurity B

CAS: 167074-97-7

Formula: C₄₃H₅₁NO₁₄

Molecular weight: 805.9

Ref: ST-EA-CP-D32002

10-Oxo Docetaxel

CAS: 167074-97-7

Impurity Docetaxel EP Impurity B
Stability Epimerize in solution
Applications 10-Oxo Docetaxel (Docetaxel EP Impurity B) is a novel taxoid having remarkable anti-tumor properties. Docetaxel (D494420) intermediate. This product is unstable in solution, epimerize.
References Appendino, G., et al.: Tetrahedron Lett., 37, 7836 (1996),

Formula: C₄₃H₅₁NO₁₄

Color and Shape: Neat

Molecular weight: 805.86

Ref: TR-O855800

10-Oxo docetaxel

CAS: 167074-97-7

10-Oxo docetaxel is a taxane that is used in the treatment of cancer. It has shown to be effective in the treatment of breast, lung, prostate, and bladder cancers. The impurities of this drug are 10-deacetylbaccatin III (10-DAB) and 10-deacetyltaxol (10-DT). These impurities can be quantified using LC/MS/MS methods with a limit of detection at 0.05% for 10-DAB and 0.1% for 10-DT. The limits of quantification are determined by the peak area response and signal to noise ratio. Bortezomib is an impurity that cannot be removed by chromatographic methods but can be removed by supercritical CO2 extraction. This impurity may cause significant adverse effects on patients receiving this drug as bortezomib inhibits the proteasome which is needed to break down proteins within cells that are damaged or no

Formula: C₄₃H₅₁NO₁₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 805.86 g/mol

Ref: 3D-FO26648

10-Oxo Docetaxel

CAS: 167074-97-7

Ref: BE-RMCD202092