CAS 167465-36-3: ZOSUQUIDAR TRIHYSROCHLORIDE

Description: Zosuquidar trihydrochloride, identified by its CAS number 167465-36-3, is a chemical compound primarily studied for its potential role in cancer treatment, particularly in overcoming drug resistance in leukemia and other malignancies. It functions as a selective inhibitor of the P-glycoprotein (P-gp) efflux pump, which is often overexpressed in cancer cells and contributes to multidrug resistance by expelling therapeutic agents from the cells. The compound is typically characterized by its trihydrochloride salt form, which enhances its solubility in aqueous solutions, facilitating its use in biological studies. Zosuquidar has been evaluated in various preclinical and clinical settings, demonstrating the ability to sensitize resistant cancer cells to chemotherapy. Its pharmacological profile includes a focus on safety and efficacy, with ongoing research aimed at optimizing its use in combination therapies. As with many investigational drugs, the full spectrum of its properties, including pharmacokinetics and potential side effects, continues to be explored in clinical trials.

Formula: C₃₂H₃₂ClF₂N₃O₂

InChI: InChI=1/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21?,29-,30+,31?;

Synonyms:

• Ly335979, Rs 33295-198
• 1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol hydrochloride
• Zosuquidar trihydrochloride

Zosuquidar trihydrochloride

CAS: 167465-36-3

• Formula: C₃₂H₃₄Cl₃F₂N₃O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 636.9871

Zosuquidar TriHCl

CAS: 167465-36-3

• Formula: C₃₂H₃₁F₂N₃O₂HCl
• Color and Shape: Yellow Solid
• Molecular weight: 527.62 3*36.46

Zosuquidar

CAS: 167465-36-3

• Formula: C₃₂H₃₁F₂N₃O₂
• Molecular weight: 527.60

Zosuquidar trihydrochloride

CAS: 167465-36-3

Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of …

• Formula: C₃₂H₃₁F₂N₃O₂·3HCl
• Purity: 100% - 99.55%
• Color and Shape: Solid
• Molecular weight: 636.99

Zosuquidar trihydrochloride

CAS: 167465-36-3

Inhibits P-gp transporters ; modulates P-gp-mediated multidrug resistance

• Formula: C₃₂H₃₄Cl₃F₂N₃O₂
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 636.99 g/mol

rac Zosuquidar-d5 Trihydrochloride

CAS: 167465-36-3

• Formula: C₃₂H₂₉D₅Cl₃F₂N₃O₂
• Color and Shape: Neat
• Molecular weight: 532.635

Zosuquidar Trihydrochloride

CAS: 167465-36-3

Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer). References Green, …

• Formula: C₃₂H₃₁F₂N₃O₂ClH
• Color and Shape: Neat
• Molecular weight: 636.99