CAS 167465-36-3

ZOSUQUIDAR TRIHYSROCHLORIDE

Description:

Zosuquidar trihydrochloride, identified by its CAS number 167465-36-3, is a chemical compound primarily studied for its potential role in cancer treatment, particularly in overcoming drug resistance in leukemia and other malignancies. It functions as a selective inhibitor of the P-glycoprotein (P-gp) efflux pump, which is often overexpressed in cancer cells and contributes to multidrug resistance by expelling therapeutic agents from the cells. The compound is typically characterized by its trihydrochloride salt form, which enhances its solubility in aqueous solutions, facilitating its use in biological studies. Zosuquidar has been evaluated in various preclinical and clinical settings, demonstrating the ability to sensitize resistant cancer cells to chemotherapy. Its pharmacological profile includes a focus on safety and efficacy, with ongoing research aimed at optimizing its use in combination therapies. As with many investigational drugs, the full spectrum of its properties, including pharmacokinetics and potential side effects, continues to be explored in clinical trials.

Formula: C₃₂H₃₂ClF₂N₃O₂

InChI: InChI=1/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21?,29-,30+,31?;

Synonyms:

• Ly335979, Rs 33295-198
• 1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol hydrochloride
• Zosuquidar trihydrochloride

Zosuquidar Trihydrochloride

CAS: 167465-36-3

Formula: C₃₂H₃₄Cl₃F₂N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 636.9871

Ref: IN-DA007VX7

Zosuquidar TriHCl

CAS: 167465-36-3

Formula: C₃₂H₃₁F₂N₃O₂·3HCl

Color and Shape: Yellow Solid

Molecular weight: 527.62 3*36.46

Ref: 4Z-Z-023001

Zosuquidar trihydrochloride

CAS: 167465-36-3

Zosuquidar trihydrochloride

Purity: ≥98%

Molecular weight: 636.99g/mol

Ref: 54-BUP04878

Zosuquidar

CAS: 167465-36-3

Formula: C₃₂H₃₁F₂N₃O₂

Molecular weight: 527.60

Ref: 7W-GP1336

Zosuquidar trihydrochloride

CAS: 167465-36-3

Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.

Formula: C₃₂H₃₁F₂N₃O₂·3HCl

Purity: 99.49% - >99.99%

Color and Shape: Solid

Molecular weight: 636.99

Ref: TM-T6018

Zosuquidar trihydrochloride

CAS: 167465-36-3

Inhibits P-gp transporters ; modulates P-gp-mediated multidrug resistance

Formula: C₃₂H₃₄Cl₃F₂N₃O₂

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 636.99 g/mol

Ref: 3D-FZ28787

rac Zosuquidar-d5 Trihydrochloride

Controlled Product

CAS: 167465-36-3

Formula: C₃₂H₂₉D₅Cl₃F₂N₃O₂

Color and Shape: Neat

Molecular weight: 532.635

Ref: TR-Z700872

Zosuquidar Trihydrochloride

Controlled Product

CAS: 167465-36-3

Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).
References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),

Formula: C₃₂H₃₁F₂N₃O₂·3ClH

Color and Shape: Neat

Molecular weight: 636.99

Ref: TR-Z700870