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CAS 167465-36-3

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ZOSUQUIDAR TRIHYSROCHLORIDE

Description:
Zosuquidar trihydrochloride, identified by its CAS number 167465-36-3, is a chemical compound primarily studied for its potential role in cancer treatment, particularly in overcoming drug resistance in leukemia and other malignancies. It functions as a selective inhibitor of the P-glycoprotein (P-gp) efflux pump, which is often overexpressed in cancer cells and contributes to multidrug resistance by expelling therapeutic agents from the cells. The compound is typically characterized by its trihydrochloride salt form, which enhances its solubility in aqueous solutions, facilitating its use in biological studies. Zosuquidar has been evaluated in various preclinical and clinical settings, demonstrating the ability to sensitize resistant cancer cells to chemotherapy. Its pharmacological profile includes a focus on safety and efficacy, with ongoing research aimed at optimizing its use in combination therapies. As with many investigational drugs, the full spectrum of its properties, including pharmacokinetics and potential side effects, continues to be explored in clinical trials.
Formula:C32H32ClF2N3O2
InChI:InChI=1/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21?,29-,30+,31?;
InChI key:ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
SMILES:C1CN(CCN1C[C@H](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[C@H]6[C@H](C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
Synonyms:
  • Ly335979, Rs 33295-198
  • 1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol hydrochloride
  • Zosuquidar trihydrochloride
Found 11 products.