CAS 167698-68-2

BENZYLOXYCARBONYL-L-LEUCYL-L-ARGINYLGLYCYLGLYCINE 4-METHYLCOUMARYL-7-AMIDE

Description:

Benzyloxycarbonyl-L-leucyl-L-arginylglycylglycine 4-methylcoumaryl-7-amide, identified by its CAS number 167698-68-2, is a synthetic peptide compound often utilized in biochemical research, particularly in studies involving proteolytic enzymes and peptide interactions. This compound features a complex structure that includes a benzyloxycarbonyl (Z) protecting group, which is commonly used to shield the amino group of the amino acid leucine during peptide synthesis. The presence of the 4-methylcoumaryl-7-amide moiety indicates that it may be used as a fluorescent probe, allowing for the detection of enzymatic activity through fluorescence resonance energy transfer (FRET) mechanisms. The peptide sequence itself, comprising leucine, arginine, glycine, and glycine, suggests potential biological activity, possibly influencing cellular processes or serving as a substrate for specific enzymes. Overall, this compound is significant in the field of peptide chemistry and molecular biology, providing insights into enzyme kinetics and substrate specificity.

Formula: C₃₄H₄₄N₈O₈

Synonyms:

• Z-Lrgg-Amc
• Z-Leu-Arg-Gly-Gly-Mca
• Z-Leu-Arg-Gly-Gly-7-Amino-4-Methylcoumarin Amc
• Z-Leu-Arg-Gly-Gly-Amc

Z-Leu-Arg-Gly-Gly-AMC

CAS: 167698-68-2

Z-LRGG-AMC is a fluorogenic substrate for isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs) based on the C-termini of ubiquitin with a kcat/Km value of 18 M⁻¹s⁻¹. Together with our product I-1690 it forms the basis of continuous assays for precise mechanistic studies or microtiter plate assays for high-throughput inhibitor screening. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and 7. Stock solutions of Boc-LRGG-AMC are best prepared in DMSO.

Formula: C₃₄H₄₄N₈O₈

Purity: 98.8%

Color and Shape: White

Molecular weight: 692.77

Ref: 01-4027157

Z-Leu-Arg-Gly-Gly-AMC

CAS: 167698-68-2

Formula: C₃₄H₄₄N₈O₈·C₂HF₃O₂

Molecular weight: 806.8

Ref: 7W-GL8968

Z-Leu-Arg-Gly-Gly-AMC acetate salt

Controlled Product

CAS: 167698-68-2

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Formula: C₃₄H₄₄N₈O₈

Purity: Min. 95%

Molecular weight: 692.76 g/mol

Ref: 3D-FL110571