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CAS 16783-99-6

:

25-Desacetylrifampicin

Description:
25-Desacetylrifampicin, with the CAS number 16783-99-6, is a derivative of rifampicin, an antibiotic commonly used to treat bacterial infections, particularly tuberculosis. This compound is characterized by its structural modification, specifically the removal of an acetyl group from the rifampicin molecule, which influences its pharmacological properties. It exhibits antibacterial activity by inhibiting bacterial RNA synthesis, thereby preventing the growth and replication of susceptible bacteria. The compound is typically a reddish-orange solid, reflecting the color associated with rifampicin derivatives. Its solubility profile is generally moderate, with varying solubility in organic solvents and limited solubility in water. 25-Desacetylrifampicin is of interest in medicinal chemistry for its potential therapeutic applications and as a subject of research in understanding antibiotic resistance mechanisms. Safety and handling precautions are essential, as with many antibiotics, due to potential toxicity and the risk of developing resistance in bacterial populations.
Formula:C41H56N4O11
InChI:InChI=1/C41H56N4O11/c1-20-11-10-12-21(2)40(53)43-31-26(19-42-45-16-14-44(8)15-17-45)36(50)28-29(37(31)51)35(49)25(6)38-30(28)39(52)41(7,56-38)55-18-13-27(54-9)22(3)33(47)24(5)34(48)23(4)32(20)46/h10-13,18-20,22-24,27,32-34,42,46-49,51H,14-17H2,1-9H3,(H,43,53)/b11-10+,18-13+,21-12+,26-19+/t20-,22+,23+,24-,27-,32-,33+,34+,41-/m0/s1
InChI key:InChIKey=KUJZTIJOBQNKDR-OACVHIRKSA-N
SMILES:OC1=C2C3=C4O[C@@](C)(C3=O)O/C=C/[C@H](OC)[C@@H](C)[C@@H](O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)NC(C(O)=C2C(O)=C4C)=C1/C=N/N5CCN(C)CC5
Synonyms:
  • (2S,8E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{[(4-methylpiperazin-1-yl)amino]methylidene}-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,9,11(2H,8H)-trione
  • (2S,8E,16S,17S,18R,19R,20R,21S,22S,23S,24E)-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{[(4-methylpiperazin-1-yl)amino]methylidene}-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,9,11(2H,8H)-trione
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-
  • 25-Deacetylrifampicin
  • 25-Desacetylrifampicin
  • 25-Desacetylrifampin
  • 25-O-Deacetyl-3-[(E)-[(4-methyl-1-piperazinyl)imino]methyl]rifamycin
  • 25-O-Deacetylrifampicin
  • 25-O-Desacetylrifampin
  • See more synonyms
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