CAS 1678415-83-2

(Val3)-Amyloid β-Protein (1-40)

Description:

(Val3)-Amyloid β-Protein (1-40), with the CAS number 1678415-83-2, is a peptide that is a variant of the amyloid beta protein, which is primarily associated with Alzheimer's disease. This specific variant features a valine substitution at the third position of the amino acid sequence, which can influence its aggregation properties and biological activity. The peptide consists of 40 amino acids and is known for its propensity to form fibrillar aggregates, a hallmark of amyloid pathology. Its structure includes hydrophobic regions that facilitate self-assembly into oligomers and fibrils, contributing to neurotoxicity. The (Val3) modification may alter its interactions with other proteins and cellular components, potentially affecting its role in neurodegenerative processes. Research on this peptide is crucial for understanding amyloid-related diseases and developing therapeutic strategies. Overall, (Val3)-Amyloid β-Protein (1-40) serves as an important model for studying amyloid formation and its implications in neurodegeneration.

Synonyms:

• (Val3)-Amyloid β-Protein (1-40)
• (Va34)-Amyloid β-Protein (1-40)
• (Val??)-Amyloid β-Protein (1-40)
• (Val3?)-Amyloid β-Protein (1-40) trifluoroacetate salt
• (Val34)-Amyloid β-Protein (1-40)

(Val34)-Amyloid b-Protein (1-40) trifluoroacetate salt

CAS: 1678415-83-2

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Formula: C₁₉₃H₂₉₃N₅₃O₅₈S

Purity: Min. 95%

Molecular weight: 4,315.78 g/mol

Ref: 3D-FV110093

(Val³⁴)-Amyloid β-Protein (1-40)

CAS: 1678415-83-2

Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.

Formula: C₁₉₃H₂₉₃N₅₃O₅₈S

Purity: >95%

Color and Shape: White Powder

Molecular weight: 4315.84

Ref: 01-4089805