As of my last update in October 2023, there is no widely recognized chemical substance known as "FzM1" with the CAS number "1680196-54-6." It is possible that this compound is either a newly synthesized substance, a proprietary compound, or a less common chemical that has not yet gained significant attention in the scientific literature. Typically, chemical substances are characterized by their molecular structure, physical properties (such as melting and boiling points), solubility, reactivity, and potential applications. To obtain accurate and detailed information about a specific compound, including its characteristics, it is advisable to consult scientific databases, peer-reviewed journals, or chemical suppliers that may have more recent data. If "FzM1" is a novel compound, further research may be necessary to elucidate its properties and potential uses.

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 μM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.

FzM1

1680196-54-6: As of my last update in October 2023, there is no widely recognized chemical substance known as "FzM1" with the CAS number "1680196-54-6." It is possible that this compound is either a newly synthesized substance, a proprietary compound, or a less common chemical that has not yet gained significant attention in the scientific literature. Typically, chemical substances are characterized by their molecular structure, physical properties (such as melting and boiling points), solubility, reactivity, and potential applications. To obtain accurate and detailed information about a specific compound, including its characteristics, it is advisable to consult scientific databases, peer-reviewed journals, or chemical suppliers that may have more recent data. If "FzM1" is a novel compound, further research may be necessary to elucidate its properties and potential uses.

FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)

CAS 1680196-54-6

FzM1

FzM1

Ref: 54-BUP12138

FzM1

Ref: TM-T24076