CAS 169274-78-6

(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol

Description:

The chemical substance known as (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol, with the CAS number 169274-78-6, is a chiral compound characterized by its complex structure featuring a piperidine ring. This compound contains a hydroxyl group, which contributes to its potential as a pharmacological agent, possibly influencing its solubility and reactivity. The presence of multiple aromatic rings, including a phenylmethyl group, suggests that it may exhibit significant interactions with biological targets, potentially affecting its pharmacodynamics and pharmacokinetics. The stereochemistry indicated by the (αR,βS) notation implies specific spatial arrangements of its atoms, which can be crucial for its biological activity. Such compounds are often studied for their potential therapeutic applications, particularly in the fields of neuroscience and psychiatry, where piperidine derivatives are known to play a role in modulating neurotransmitter systems. Overall, this substance represents a class of compounds that may have valuable applications in medicinal chemistry and drug development.

Formula: C₂₂H₂₉NO₂

InChI: InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1

InChI key: InChIKey=WVZSEUPGUDIELE-HTAPYJJXSA-N

SMILES: C(C1CCN(C[C@@H]([C@@H](O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3

Synonyms:

• (alpha-R,beta-S)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate
• (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol
• 1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, (αR,βS)-
• 1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, [R-(R*,S*)]-
• 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
• Ro 25-6981
• Ro 25-6981 Maleate
• MI 4

Ro 25-6981

CAS: 169274-78-6

Ro 25-6981

Purity: ≥98%

Molecular weight: 339.47g/mol

Ref: 54-BUP08836

RO 25-6981 Maleate

CAS: 169274-78-6

RO 25-6981 Maleate is a selective sigma receptor agonist that has been shown to have antidepressant, neuroprotective, and anti-pain effects. RO 25-6981 Maleate inhibits glutamate release in the hippocampus, which is related to the neuroprotective effect of this drug. It also affects locomotor activity, response element-binding protein expression in the caudate putamen, and rotarod performance in mice. RO 25-6981 Maleate also has an affinity for dopamine receptors and may be used as a potential treatment for Parkinson's disease.

Formula: C₂₆H₃₃NO₆

Purity: Min. 95%

Molecular weight: 455.55 g/mol

Ref: 3D-UGA27478

Ro 25-6981

CAS: 169274-78-6

Ro 25-6981: potent, selective NMDA receptor blocker (NR2B), IC50: 0.009 μM (NR1C/NR2B), 52 μM (NR1C/NR2A), useful in Parkinson's research.

Formula: C₂₂H₂₉NO₂

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 339.47

Ref: TM-T12758