CAS 16960-16-0

Tetracosactide

Description:

Tetracosactide, also known as tetracosactide acetate, is a synthetic peptide that consists of a sequence of 24 amino acids, specifically a fragment of adrenocorticotropic hormone (ACTH). It is primarily used in medical applications for its ability to stimulate the adrenal cortex, leading to increased production of corticosteroids. Tetracosactide is characterized by its role in diagnostic tests for adrenal insufficiency and as a therapeutic agent in conditions like multiple sclerosis and certain types of inflammatory diseases. The substance is typically administered via injection and is known for its relatively long half-life compared to other ACTH derivatives. Its molecular structure includes a specific arrangement of amino acids that contributes to its biological activity, and it is often stored under controlled conditions to maintain stability. As with many peptides, tetracosactide may exhibit variability in its effects based on dosage and individual patient response, necessitating careful monitoring during treatment.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

InChI: InChI=1/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

SMILES: CC(C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)N1CCC[C@H]1C(=O)O)O)O)O)O)O)O)O)O)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C(CN=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](CCCNC(=N)N)N=C([C@H](Cc1ccccc1)N=C([C@H](Cc1cnc[nH]1)N=C([C@H](CCC(=O)O)N=C([C@H](CCSC)N=C([C@H](CO)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](CO)N)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• Cosyntropin
• L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
• ACTH(1-24),human
• (1-24)α-ACTH
• 10: PN: WO03051390 PAGE: 52 claimed protein
• 1-24 ACTH (human)
• 1-24 Corticotropin (Human)
• 2136: PN: WO03060071 SEQID: 2198 unclaimed
• Acth1-24
• Actholain
• ACTHα1-24
• Adrenocorticotropin(1-24)
• Ba 30920
• Ba 36716
• Corticotropin-(1-24)
• Cortrophin S
• Cortrosinta
• Cortrosyn
• Human ACTH (1-24)
• L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-α-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-
• Nuvacthen Depot
• PN: WO9952928 SEQID: 9 claimed protein
• Porcine ACTH (1-24)
• Synacthen
• Synacthene
• Synacthene-retard
• Synecthen
• Tetracosactid
• Tetracosactida
• Tetracosactrin
• Tetracosapeptide
• α1-24-ACTH
• α1-24-Adrenocorticotropic hormone
• α1-24-Corticotropin
• β1-24-ACTH
• β1-24-Corticotropin
• β1-24-Tetracosactide

ACTH (1-24) (human, bovine, rat)

CAS: 16960-16-0

Tetracosactide, a C-terminally truncated ACTH, still exhibits corticotropic activity, but it is less immunogenic than the full-length peptide hormone. The peptide induces an increase in the circulating level of glucocorticoids.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: 96.2%

Color and Shape: White

Molecular weight: 2933.48

Ref: 01-4011958

TETRACOSACTIDE CRS

CAS: 16960-16-0, 69-65-8

TETRACOSACTIDE CRS

Ref: 41-Y0002501

Tetracosactide acetate

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: ≥ 95% (dry, solvent free basis)

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 2933.44

Ref: 7W-GX2798

Tetracosactide Acetate

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 2933.44

Ref: BP-BPPG064

Tetracosactide

CAS: 16960-16-0

Tetracosactide, a synthetic peptide, mirrors the 24-amino acid start of ACTH with sequence SYSMEHFRWGKPVGKKRRPVKVYP.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 2933.44

Ref: TM-TP1031

α1-24-Adrenocorticotropic-d4 Hormone TFA Salt

Controlled Product

CAS: 16960-16-0

Applications α1-24-Adrenocorticotropic-d4 Hormone is the labeled analog of α1-24-Adrenocorticotropic Hormone (A305290), which is used in the treatment of West syndrome (WS).
References Munakata, M., et. al.: Tohoku J. Exp. Med., 232, 273 (2014);

Formula: C₁₃₆H₂₀₆D₄N₄₀O₃₁S•x(C₂HF₃O₂)

Color and Shape: Off-White

Molecular weight: 2937.4611402

Ref: TR-A305292

ACTH (1-24), human

CAS: 16960-16-0

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Molecular weight: 2,933.5 g/mol

Ref: 3D-PP50154

ACTH (Human 1-24)

CAS: 16960-16-0

ACTH (1-24) is a peptide hormone and neurotransmitter that belongs to the corticotropin-releasing factor family. It is also known as corticotropin-releasing hormone, adrenocorticotropic hormone, or CRH. ACTH binds to the ACTH receptor, which activates protein kinase A and cyclic AMP response element binding protein (CREB). Activation of these proteins leads to an increase in the production of cortisol. ACTH can be used as a research tool for studying ion channels and ligands. It can also be used as an antibody in cell biology research.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: Min. 95%

Molecular weight: 2,933.4 g/mol

Ref: 3D-PAC-4109-V

ACTH (1-24), human

CAS: 16960-16-0

Custom research peptide; min purity 95%.

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: Min. 95%

Molecular weight: 2,933.5 g/mol

Ref: 3D-PA16890

Tetracosactide

CAS: 16960-16-0

Formula: C₁₃₆H₂₁₀N₄₀O₃₁S

Purity: 99%

Color and Shape: Solid

Molecular weight: 2933.4370

Ref: IN-DA019FUR