CAS 170006-73-2

FTI 277

Description:

FTI 277, with the CAS number 170006-73-2, is a small molecule that functions primarily as a selective inhibitor of the protein farnesyltransferase. This enzyme is crucial in the post-translational modification of proteins, particularly in the farnesylation of Ras proteins, which are implicated in various cancers. FTI 277 has been studied for its potential therapeutic applications in oncology, particularly in targeting tumors that exhibit aberrant Ras signaling. The compound is characterized by its ability to disrupt the farnesylation process, thereby inhibiting the localization and function of Ras proteins at the cell membrane. In terms of its chemical properties, FTI 277 is typically described as a lipophilic compound, which may influence its bioavailability and pharmacokinetics. Research has indicated that FTI 277 can induce apoptosis in cancer cells and may enhance the efficacy of other anticancer agents. However, further studies are necessary to fully understand its mechanism of action and potential side effects in clinical settings.

Formula: C₂₂H₂₉N₃O₃S₂

InChI: InChI=1S/C22H29N3O3S2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26)/t16-,20+/m1/s1

InChI key: InChIKey=GKFPROVOIQKYTO-UZLBHIALSA-N

SMILES: C(N[C@@H](CCSC)C(OC)=O)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C2=CC=CC=C2

Synonyms:

• <span class="text-smallcaps">L</span>-Methionine, N-[[5-[(2-amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-, methyl ester, (R)-
• <span class="text-smallcaps">L</span>-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-, methyl ester
• Methyl[N-[2-Phenyl-4-N-[2(R)-Amino-3-Mercaptopropylamino] Benzoyl]]-Methionate, Tfa
• N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt
• L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-, methyl ester
• L-Methionine, N-[[5-[(2-amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-, methyl ester, (R)-
• FTI 277
• FTI-277;FTI277
• N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-methionine methyl ester

Methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-carbonyl)-L-methioninate

CAS: 170006-73-2

Methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-carbonyl)-L-methioninate

Formula: C₂₂H₂₉N₃O₃S₂

Purity: ≥95%

Molecular weight: 447.61

Ref: 54-OR1134021

Methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-carbonyl)-L-methioninate

CAS: 170006-73-2

Formula: C₂₂H₂₉N₃O₃S₂

Purity: 95%

Color and Shape: Liquid

Molecular weight: 447.6140

Ref: IN-DA00AB91

FTI-277 trifluoroacetate salt

CAS: 170006-73-2

Formula: C₂₂H₂₉N₃O₃S₂·xC₂HF₃O₂

Molecular weight: 447.61 (free base b

Ref: 7W-GK6701

FTI-277

CAS: 170006-73-2

FTI-277, an FTase inhibitor, blocks H-Ras/K-Ras signaling and HDV infection; mimics Ras CAAX peptide.

Formula: C₂₂H₂₉N₃O₃S₂

Purity: 99.63%

Color and Shape: White Solid

Molecular weight: 447.61

Ref: TM-T62675

FTI-277 Trifluoroacetate Salt

CAS: 170006-73-2

Formula: C₂₂H₂₉N₃O₃S₂·C₂HF₃O₂

Molecular weight: 447.61 114.02

Ref: 4Z-F-141001

FTI-277 trifluoroacetate salt

CAS: 170006-73-2

FTI-277 trifluoroacetate salt is a synthetic biochemical compound, classified as a farnesyltransferase inhibitor (FTI). This compound is derived through chemical synthesis, aimed at disrupting specific molecular pathways. Its primary mode of action involves the inhibition of farnesyltransferase, an enzyme responsible for post-translational modification of certain proteins through the addition of a farnesyl group. By preventing this modification, FTI-277 impedes the proper localization and function of these proteins, which are often involved in oncogenic pathways.

Formula: C₂₂H₂₉N₃O₃S₂·xC₂HF₃O₂

Purity: Min. 95%

Molecular weight: 561.64 g/mol

Ref: 3D-VGA00673