CAS 170632-41-4

Benzoic acid, 4-[1-(phenylmethyl)-1H-indazol-3-yl]-, ethyl ester

Formula: C₂₃H₂₀N₂O₂

InChI: InChI=1S/C23H20N2O2/c1-2-27-23(26)19-14-12-18(13-15-19)22-20-10-6-7-11-21(20)25(24-22)16-17-8-4-3-5-9-17/h3-15H,2,16H2,1H3

InChI key: LPROLPQTWKDPNU-UHFFFAOYSA-N

SMILES: CCOC(=O)C1=CC=C(C=C1)C2=NN(C3=CC=CC=C32)CC4=CC=CC=C4

Synonyms:

• Benzoic acid, 4-[1-(phenylmethyl)-1H-indazol-3-yl]-, ethyl ester

YD-3

CAS: 170632-41-4

YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC(50)=28.3 microM). In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.

Formula: C₂₃H₂₀N₂O₂

Color and Shape: Solid

Molecular weight: 356.42

Ref: TM-T202985