CAS 170809-51-5

astressin

Description:

Astressin, with the CAS number 170809-51-5, is a synthetic peptide that acts as a corticotropin-releasing factor (CRF) antagonist. It is primarily used in research to study the role of CRF in stress responses and related physiological processes. Astressin is characterized by its ability to inhibit the actions of CRF, which is involved in the hypothalamic-pituitary-adrenal (HPA) axis and plays a crucial role in the body’s response to stress. The peptide is typically administered in experimental settings to investigate its effects on anxiety, depression, and other stress-related disorders. Astressin's structure consists of a sequence of amino acids that confer its biological activity, and it is often used in animal models to explore potential therapeutic applications. Due to its specific action on CRF receptors, astressin is valuable in pharmacological studies aimed at understanding stress mechanisms and developing treatments for stress-related conditions.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

InChI: InChI=1/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88-,89-,90-,91-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-/m0/s1

Synonyms:

• H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

Astressin

CAS: 170809-51-5

The Glu³⁰ to Lys³³ lactam bridge constrains astressin in an α-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than α-helical CRF (9-41) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purity: 97.4%

Color and Shape: White Powder

Molecular weight: 3563.24

Ref: 01-4026664

Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 trifluoroacetate salt

CAS: 170809-51-5

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 3563.1617

Ref: IN-DA01E6VT

Astressin

CAS: 170809-51-5

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Molecular weight: 3563.16

Ref: 7W-GK2573

Astressin

CAS: 170809-51-5

Astressin is a truncated CRF analog; binds strongly to receptor's extracellular domain, likely acting as a neutral competitive antagonist.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 3563.16

Ref: TM-TP1448

Astressin trifluoroacetate salt

CAS: 170809-51-5

Astressin trifluoroacetate salt H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln is a cyclic peptide that has been shown to have biological properties as an inhibitor of cyclases. Astressin has shown efficacy in treating some types of autoimmune diseases and bowel diseases, although it is not effective against all types of these disorders. Astressin also has receptor activity and can induce locomotor activity. This compound has been shown to be an inhibitor of the Toll like receptor 4 (TLR4). In this role, astressin blocks the inflammatory response by preventing the binding of endotoxin to TLR4 receptors on cells.

Formula: C₁₆₁H₂₆₉N₄₉O₄₂

Purity: Min. 95%

Molecular weight: 3,563.16 g/mol

Ref: 3D-FA108999