CAS 171596-36-4
:DeMethyltadalafil
Description:
DeMethyltadalafil, identified by its CAS number 171596-36-4, is a chemical compound that is structurally related to tadalafil, a well-known phosphodiesterase type 5 (PDE5) inhibitor used primarily for the treatment of erectile dysfunction and pulmonary arterial hypertension. DeMethyltadalafil is characterized by the removal of a methyl group from the tadalafil structure, which may influence its pharmacological properties and biological activity. The compound typically exhibits a similar mechanism of action, promoting vasodilation and increased blood flow by inhibiting the breakdown of cyclic guanosine monophosphate (cGMP). Its solubility, stability, and interaction with biological systems can vary compared to its parent compound, potentially affecting its efficacy and safety profile. As with many pharmaceutical compounds, the specific characteristics, including potency, half-life, and side effects, would require detailed experimental data and clinical studies to fully understand its therapeutic potential and applications.
Formula:C21H17N3O4
InChI:InChI=1S/C21H17N3O4/c25-18-9-22-21(26)15-8-13-12-3-1-2-4-14(12)23-19(13)20(24(15)18)11-5-6-16-17(7-11)28-10-27-16/h1-7,15,20,23H,8-10H2,(H,22,26)/t15-,20-/m1/s1
InChI key:XHDLVMPUSXRZOS-FOIQADDNSA-N
SMILES:C1[C@@H]2C(=O)NCC(=O)N2[C@@H](C3=C1C4=CC=CC=C4N3)C5=CC6=C(C=C5)OCO6
Synonyms:- Nortadalafi
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(6R,12Ar)-6-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-b]Indole-1,4-Dione
CAS:(6R,12Ar)-6-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-b]Indole-1,4-DioneFormula:C21H17N3O4Purity:98%Molecular weight:375.38Desmethyltadalafil (Nortadalafil)
CAS:Formula:C21H17N3O4Color and Shape:White To Light YellowMolecular weight:375.38Desmethyltadalafil (Nortadalafil)
CAS:Controlled ProductFormula:C21H17N3O4Color and Shape:NeatMolecular weight:375.38Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-
CAS:Formula:C21H17N3O4Purity:98%Color and Shape:SolidMolecular weight:375.3774N-Desmethyl Tadalafil
CAS:Controlled ProductApplications A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.
References Beghyn, T. et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007); Daugan, A. et al.: J. Med. Chem., 46, 4533 (2003);Formula:C21H17N3O4Color and Shape:NeatMolecular weight:375.38Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Formula:C21H17N3O4Purity:99.42%Color and Shape:White SolidMolecular weight:375.3774Nortadalafil
CAS:(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dioneFormula:C21H17N3O4Purity:98%Molecular weight:375.38
