CAS 171599-83-0: sildenafil citrate
Description:Sildenafil citrate is a pharmaceutical compound primarily known for its use in treating erectile dysfunction and pulmonary arterial hypertension. It functions as a selective inhibitor of phosphodiesterase type 5 (PDE5), which enhances the effects of nitric oxide by increasing levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, leading to vasodilation and improved blood flow. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Its molecular formula is C22H30N6O4S, and it has a molecular weight of approximately 474.6 g/mol. Sildenafil citrate is typically administered in tablet form, with various dosages available, and is known to have a relatively rapid onset of action. Common side effects may include headaches, flushing, and dyspepsia, while contraindications include the use of nitrates and certain cardiovascular conditions. Overall, sildenafil citrate has significantly impacted the treatment of erectile dysfunction since its introduction, improving the quality of life for many individuals.
Formula:C22H30N6O4S·C6H8O7
InChI:InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key:InChIKey=DEIYFTQMQPDXOT-UHFFFAOYSA-N
SMILES:O=C1N=C(NC=2C(=NN(C12)C)CCC)C=3C=C(C=CC3OCC)S(=O)(=O)N4CCN(C)CC4.O=C(O)CC(O)(C(=O)O)CC(=O)O
- Synonyms:
- 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one citrate
- 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
- 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-2,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
- 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Actra-R<sub>x</sub>
- Alisiga
- Apodefil
- Caverta 100
- Edegra
- See more synonyms
- Granpidam
- Kamagra
- Maxifort
- Mysildecard
- Niagra Actra-R<sub>x</sub>
- Penegra
- Piperazine, 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Sidenafil citrate
- Sildegra
- Sildigra
- Siligra
- Sollevare
- Tonafil
- Uk 92480
- Uk 92480-10
- Vega (pharmaceutical)
- Viagra
- Vigrex
- Zenegra
- Sildenafil citrate
