CAS 171599-83-0

sildenafil citrate

Description:

Sildenafil citrate is a pharmaceutical compound primarily known for its use in treating erectile dysfunction and pulmonary arterial hypertension. It functions as a selective inhibitor of phosphodiesterase type 5 (PDE5), which enhances the effects of nitric oxide by increasing levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, leading to vasodilation and improved blood flow. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Its molecular formula is C22H30N6O4S, and it has a molecular weight of approximately 474.6 g/mol. Sildenafil citrate is typically administered in tablet form, with various dosages available, and is known to have a relatively rapid onset of action. Common side effects may include headaches, flushing, and dyspepsia, while contraindications include the use of nitrates and certain cardiovascular conditions. Overall, sildenafil citrate has significantly impacted the treatment of erectile dysfunction since its introduction, improving the quality of life for many individuals.

Formula: C₂₈H₃₈N₆O₁₁S

InChI: InChI=1/C21H28N6O4S/c1-4-6-16-18-19(25-24-16)21(28)23-20(22-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-26(3)10-12-27/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,25)(H,22,23,28)

InChI key: InChIKey=DEIYFTQMQPDXOT-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(C)CC2)C=C1)C=3NC4=C(C(=O)N3)N(C)N=C4CCC.C(CC(O)=O)(CC(O)=O)(C(O)=O)O

Synonyms:

• 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one citrate
• 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-2,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Actra-R_x
• Alisiga
• Apodefil
• Caverta 100
• Edegra
• Granpidam
• Kamagra
• Maxifort
• Mysildecard
• Niagra Actra-R_x
• Penegra
• Piperazine, 1-[[3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
• Sidenafil citrate
• Sildegra
• Sildigra
• Siligra
• Sollevare
• Tonafil
• Uk 92480
• Uk 92480-10
• Vega (pharmaceutical)
• Viagra
• Vigrex
• Zenegra
• Sildenafil citrate
• 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, Citrate
• SILDENAFIL CITRATE(RG)
• uk92480-10
• 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
• SildenafilCitrate/SildenafilBaseC28H38N6O11S
• 5(2-ETHOXY-5(4-METHYLPIPERAZINE)SULPHONYLPHENYL)-1
• din-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-,2-hydroxy-1,2,3-propanetricarbo
• piperazine,1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo(4,3-d)pyrimi
• SildenafilBaseC28H38N6O11S
• 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
• SILDANAFIL CITRATE (BULK)

Sildenafil Citrate

CAS: 139755-83-2, 171599-83-0

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 666.70

Ref: 3B-S0986

Sildenafil citrate

CAS: 171599-83-0

Color and Shape: Neat

Ref: LP-SIL-984-CI-10

Sildenafil citrate, 1mg/ml in Methanol (as free base)

CAS: 171599-83-0

Color and Shape: Single Solution

Ref: LP-SIL-984-CI-1LM

Sildenafil citrate

CAS: 171599-83-0

Color and Shape: Neat

Ref: 61-FOR0254.00

SILDENAFIL FOR PEAK IDENTIFICATION CRS

CAS: 171599-83-0

SILDENAFIL FOR PEAK IDENTIFICATION CRS

Formula: C₂₈H₃₈N₆O₁₁S

Molecular weight: 666.6999

Ref: 41-Y0001891

SILDENAFIL CITRATE CRS

CAS: 171599-83-0

SILDENAFIL CITRATE CRS

Formula: C₂₈H₃₈N₆O₁₁S

Molecular weight: 666.6999

Ref: 41-Y0001578

Sildenafil Citrate

CAS: 171599-83-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 474.20492

Ref: 45-1612561

Sildenafil citrate

CAS: 171599-83-0

Sildenafil citrate, a PDE5 inhibitor for erectile dysfunction and occasionally pulmonary hypertension.

Formula: C₂₈H₃₈N₆O₁₁S

Purity: 99.59% - 99.97%

Color and Shape: White Solid

Molecular weight: 666.70

Ref: TM-T0467

Sildenafil Citrate

CAS: 171599-83-0

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Color and Shape: White To Off-White Solid

Molecular weight: 474.58 192.12

Ref: 4Z-S-061

Sildenafil citrate

CAS: 171599-83-0

Sildenafil citrate

Purity: ≥98%

Molecular weight: 666.7g/mol

Ref: 54-BUP17834

Sildenafil citrate

CAS: 171599-83-0

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Purity: ≥ 99.0% (dried basis)

Color and Shape: White powder

Molecular weight: 666.70

Ref: 7W-GP3242

Sildenafil citrate

CAS: 171599-83-0

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Color and Shape: Neat

Molecular weight: 666.70

Ref: 04-C16946500

Sildenafil Citrate

CAS: 171599-83-0

Color and Shape: Neat

Ref: 86-MM0254.00

Sildenafil Citrate

Controlled Product

CAS: 171599-83-0

Stability Store in Freezer
Applications Sildenafil Citrate is an orally active selective type 5 cGMP phosphodiesterase inhibitor.
References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996), Goldstein, I., et al.: N. Engl. J. Med., 338, 1397 (1998),

Formula: C₂₂H₃₀N₆O₄S·C₆H₈O₇

Color and Shape: White To Off-White

Molecular weight: 666.70

Ref: TR-S435000

Sildenafil Citrate-d3

Controlled Product

CAS: 171599-83-0

Formula: C₂₂H₂₇D₃N₆O₄S•(C₆H₈O₇)

Color and Shape: Off-White

Molecular weight: 669.71

Ref: TR-S435004

Sildenafil citrate

CAS: 171599-83-0

Sildenafil is an inhibitor of phosphodiesterase type-5 (PDE-5). It is used in the treatment of erectile dysfunction. Sildenafil inhibits the enzyme phosphodiesterase type-5, which prevents the conversion of cyclic guanosine monophosphate to cyclic adenosine monophosphate, and this results in relaxation of smooth muscle cells and increased blood flow to the corpus cavernosum. The PDE-5 inhibitors are selective for human PDE-5 and do not inhibit PDEs 1, 2, 3, or 6. The inhibition of PDE-5 by sildenafil is reversible. Sildenafil has been shown to be a potent inhibitor of cyclase activity in vitro. br> The LC/MS/MS method was developed to measure the concentration of sildenafil in human serum. This analytical method provides a linear calibration curve with limits of quant

Formula: C₂₈H₃₈N₆O₁₁S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 666.7 g/mol

Ref: 3D-FS27829

Sildenafil citrate - Bio-X ™

CAS: 171599-83-0

A potent selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5), thereby reducing the degradation rate of cGMP. Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.
Sildenafil citrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₈H₃₈N₆O₁₁S

Purity: Min. 95%

Molecular weight: 666.7 g/mol

Ref: 3D-BS164405