CAS 172732-68-2

Varespladib

Description:

Varespladib is a synthetic compound classified as a phospholipase A2 inhibitor, primarily developed for therapeutic applications in inflammatory diseases and cardiovascular conditions. Its chemical structure features a substituted phenyl group and a long-chain fatty acid moiety, which contribute to its biological activity. Varespladib functions by inhibiting the action of phospholipase A2 enzymes, thereby reducing the release of arachidonic acid and subsequent production of pro-inflammatory mediators. This mechanism positions it as a potential treatment for conditions such as atherosclerosis and asthma. The compound is typically administered in a pharmaceutical formulation, and its efficacy and safety profile have been evaluated in various clinical trials. Varespladib is characterized by its moderate solubility in organic solvents and limited solubility in water, which influences its bioavailability and formulation strategies. As with many pharmacological agents, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its therapeutic application.

Formula: C₂₁H₂₀N₂O₅

InChI: InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)

InChI key: InChIKey=BHLXTPHDSZUFHR-UHFFFAOYSA-N

SMILES: C(C(N)=O)(=O)C=1C=2C(N(CC3=CC=CC=C3)C1CC)=CC=CC2OCC(O)=O

Synonyms:

• ((3-(Aminooxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetic acid
• ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid
• 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
• Acetic acid, ((3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)-,
• Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-
• Ly 315920
• Ly315920
• Unii-2Q3P98Dath
• Varepladib
• [[3-(2-Amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
• sodium ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetate
• Varespladib
• 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid
• LY-333013
• Varespladib, >98%
• [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
• CS-68
• 2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxyacetic acid
• CS-2393
• Varespladib (LY315920)
• LY315920;LY-315920 ;LY 315920

Varespladib

CAS: 172732-68-2

Formula: C₂₁H₂₀N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 380.3939

Ref: IN-DA007VP8

Varespladib

CAS: 172732-68-2

Varespladib

Formula: C₂₁H₂₀N₂O₅

Purity: ≥95%

Molecular weight: 380.39

Ref: 54-BUP02650

Varespladib

CAS: 172732-68-2

Formula: C₂₁H₂₀N₂O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 380.39

Ref: 7W-GP9821

Varespladib

CAS: 172732-68-2

Formula: C₂₁H₂₀N₂O₅

Molecular weight: 380.40

Ref: 4Z-V-107001

Varespladib

CAS: 172732-68-2

Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.

Formula: C₂₁H₂₀N₂O₅

Purity: 99.97%

Color and Shape: White Solid

Molecular weight: 380.39

Ref: TM-T2044

Varespladib

CAS: 172732-68-2

2-((3-(2-Amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetic acid

Formula: C₂₁H₂₀N₂O₅

Purity: 98%

Molecular weight: 380.39

Ref: IN-DG156361

Varespladib

Controlled Product

CAS: 172732-68-2

Secretory phospholipase A2 inhibitorÂ

Formula: C₂₁H₂₀N₂O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 380.39 g/mol

Ref: 3D-FV65203

Varespladib

CAS: 172732-68-2

Ref: BE-RMCV031000

Varespladib-d5

Controlled Product

CAS: 172732-68-2

Formula: C₂₁D₅H₁₅N₂O₅

Color and Shape: Neat

Molecular weight: 385.425

Ref: TR-V414545

2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]Acetic Acid

Controlled Product

CAS: 172732-68-2

Applications This compound is used as a PLA2 inhibitor (Phospholipase A2 Enzyme inhibitor).
References Dennis, E. et al.: Chem. Rev., 111, 6130 (2011);

Formula: C₂₁H₂₀N₂O₅

Color and Shape: Neat

Molecular weight: 380.39

Ref: TR-A618560