CAS 172732-68-2: Varespladib

Description: Varespladib is a synthetic compound classified as a phospholipase A2 inhibitor, primarily developed for therapeutic applications in inflammatory diseases and cardiovascular conditions. Its chemical structure features a substituted phenyl group and a long-chain fatty acid moiety, which contribute to its biological activity. Varespladib functions by inhibiting the action of phospholipase A2 enzymes, thereby reducing the release of arachidonic acid and subsequent production of pro-inflammatory mediators. This mechanism positions it as a potential treatment for conditions such as atherosclerosis and asthma. The compound is typically administered in a pharmaceutical formulation, and its efficacy and safety profile have been evaluated in various clinical trials. Varespladib is characterized by its moderate solubility in organic solvents and limited solubility in water, which influences its bioavailability and formulation strategies. As with many pharmacological agents, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its therapeutic application.

Formula: C₂₁H₂₀N₂O₅

InChI: InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)

InChI key: InChIKey=BHLXTPHDSZUFHR-UHFFFAOYSA-N

SMILES: O=C(N)C(=O)C=1C=2C(OCC(=O)O)=CC=CC2N(C1CC)CC=3C=CC=CC3

Synonyms:

• ((3-(Aminooxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetic acid
• ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid
• 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
• Acetic acid, ((3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)-,
• Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-
• Ly 315920
• Ly315920
• Unii-2Q3P98Dath
• Varepladib
• [[3-(2-Amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid
• sodium ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetate
• Varespladib

Varespladib

CAS: 172732-68-2

• Formula: C₂₁H₂₀N₂O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 380.3939

Varespladib

CAS: 172732-68-2

• Formula: C₂₁H₂₀N₂O₅
• Purity: ≥ 98.0%
• Color and Shape: White to off-white solid
• Molecular weight: 380.39

Varespladib

CAS: 172732-68-2

Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary …

• Formula: C₂₁H₂₀N₂O₅
• Purity: 100% - ≥98%
• Color and Shape: Solid
• Molecular weight: 380.39

Varespladib

CAS: 172732-68-2

• Formula: C₂₁H₂₀N₂O₅
• Molecular weight: 380.40

Varespladib

CAS: 172732-68-2

Secretory phospholipase A2 inhibitorÂ

• Formula: C₂₁H₂₀N₂O₅
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 380.39 g/mol

Varespladib-d5

CAS: 172732-68-2

• Formula: C₂₁D₅H₁₅N₂O₅
• Color and Shape: Neat
• Molecular weight: 385.425

2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]Acetic Acid

CAS: 172732-68-2

Applications This compound is used as a PLA2 inhibitor (Phospholipase A2 Enzyme inhibitor). References Dennis, …

• Formula: C₂₁H₂₀N₂O₅
• Color and Shape: Neat
• Molecular weight: 380.39