CAS 172889-27-9

Src kinase inhibitor PP2

Description:

Src kinase inhibitor PP2 is a small molecule compound known for its role as a selective inhibitor of Src family kinases, which are involved in various cellular processes, including proliferation, differentiation, and survival. The compound is characterized by its ability to interfere with the ATP-binding site of Src kinases, thereby inhibiting their activity. This inhibition can lead to the modulation of signaling pathways associated with cancer progression and metastasis. PP2 is often utilized in research settings to study the effects of Src inhibition on cellular behavior and to explore potential therapeutic applications in cancer treatment. The compound is typically administered in vitro and has been shown to affect various cellular functions, including migration and invasion. Its chemical structure includes specific functional groups that contribute to its binding affinity and selectivity for Src kinases. As with many kinase inhibitors, the use of PP2 may also be associated with off-target effects, necessitating careful interpretation of experimental results.

Formula: C₁₅H₁₆ClN₅

InChI: InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

InChI key: InChIKey=PBBRWFOVCUAONR-UHFFFAOYSA-N

SMILES: NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C3=CC=C(Cl)C=C3

Synonyms:

• 1-(Tert-Butyl)-3-(4-Chlorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine
• 1-(Tert-Butyl)-3-(4-Chlorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
• 1-tert-Butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine
• 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-
• 3-(4-Chlorophenyl) 1-(1,1-Dimethylethyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine
• 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-(1H)-pyrazolo[3.4-d]pyrimidine-4-amine
• 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine
• 4-Amino-5-(4-Chlorophenyl)-7-(T-Butyl)Pyrazolo[3,4-D]Pyrimidine
• 4-Amino-5-(4-Chlorophenyl)-7-(Tert-Butyl)Pyrazolo[3,4-D]Pyrimidine
• Ag 1879
• Agl 1879
• PP 2 (enzyme inhibitor)
• Src kinase inhibitor PP2

PP 2

CAS: 172889-27-9

Formula: C₁₅H₁₆ClN₅

Purity: >97.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 301.78

Ref: 3B-P2833

1-(Tert-Butyl)-3-(4-Chlorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

CAS: 172889-27-9

1-(Tert-Butyl)-3-(4-Chlorophenyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

Formula: C₁₅H₁₆ClN₅

Purity: 98%

Molecular weight: 301.78

Ref: 54-OR1025666

PP2

CAS: 172889-27-9

PP2

Formula: C₁₅H₁₆ClN₅

Purity: ≥95%

Molecular weight: 301.77

Ref: 54-BUP13114

Src kinase inhibitor PP2

CAS: 172889-27-9

Formula: C₁₅H₁₆ClN₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 301.7740

Ref: IN-DA00AP0L

PP2

CAS: 172889-27-9

1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Formula: C₁₅H₁₆ClN₅

Purity: 98%

Molecular weight: 301.77

Ref: IN-DG148955

PP2

CAS: 172889-27-9

Formula: C₁₅H₁₆ClN₅

Molecular weight: 301.8

Ref: 7W-GL5082

PP2

CAS: 172889-27-9

PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.

Formula: C₁₅H₁₆ClN₅

Purity: 98.16% - 98.21%

Color and Shape: Solid

Molecular weight: 301.77

Ref: TM-T6266

PP2

Controlled Product

CAS: 172889-27-9

Applications PP 2 is a Src kinase inhibitor used in chemotherapy in the induction of leukemia cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jensen, H. et al.: PLoS One., 8, e58621 (2013); Guo, Y. et al.: Mol. Canc. Res., 11, 282 (2013);

Formula: C₁₅H₁₆ClN₅

Color and Shape: Neat

Molecular weight: 301.774

Ref: TR-P698910