CAS 17388-80-6

N-[(5-Amino-1-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-<smallcap>L</span>-aspartic acid

Description:

N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic acid, with CAS number 17388-80-6, is a chemical compound that features a complex structure combining an amino acid (L-aspartic acid) with a ribofuranosyl-imidazole moiety. This compound is characterized by its potential biological activity, particularly in the context of nucleotide metabolism and as a building block in nucleic acid synthesis. The presence of the ribofuranosyl group suggests it may play a role in biochemical pathways involving nucleotides. Additionally, the imidazole ring contributes to its potential interactions with biological macromolecules, such as enzymes and receptors. The compound is likely to be soluble in polar solvents due to its multiple functional groups, including amino and carboxyl groups, which can engage in hydrogen bonding. Its specific applications may include research in biochemistry and pharmacology, particularly in studies related to nucleoside analogs and their therapeutic potential. Overall, this compound exemplifies the intersection of amino acids and nucleoside chemistry, highlighting its relevance in biological systems.

Formula: C₁₃H₁₈N₄O₉

InChI: InChI=1S/C13H18N4O9/c14-10-7(11(23)16-4(13(24)25)1-6(19)20)15-3-17(10)12-9(22)8(21)5(2-18)26-12/h3-5,8-9,12,18,21-22H,1-2,14H2,(H,16,23)(H,19,20)(H,24,25)/t4-,5+,8+,9+,12+/m0/s1

InChI key: InChIKey=XNKLTOHYNRQCLJ-ZZZDFHIKSA-N

SMILES: NC=1N(C=NC1C(N[C@@H](CC(O)=O)C(O)=O)=O)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

Synonyms:

• N-(5-Amino-1-ribosyl-4-imidazolecarbonyl)-L-aspartic acid
• N-[(5-Amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-L-aspartic acid
• Aspartic acid, N-[(5-amino-1-β-D-ribofuranosylimidazol-4-yl)carbonyl]-, L-
• N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic acid
• L-Aspartic acid, N-[(5-amino-1-β-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-
• N-[5-Amino-1-(beta-D-ribofuranosyl)imidazole-4-carbonyl]-L-aspartic acid
• N-Succinyl-5-aMinoiMidazole-4-carboxaMide Ribose
• N-Succinyl-5-aMinoiMidazole-4-carboxaMide Ribose DisodiuM Salt

N-Succinyl-5-aminoimidazole-4-carboxamide ribose

CAS: 17388-80-6

Ref: 7W-GC4098

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose Disodium Salt

Controlled Product

CAS: 17388-80-6

Applications A metabolite of Purine. Purine metabolism by adenylosuccinasedeficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

Formula: C₁₃H₁₆N₄Na₂O₉

Color and Shape: Neat

Molecular weight: 418.267

Ref: TR-S688790

N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt

CAS: 17388-80-6

N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is a novel modified nucleoside with anticancer activity. The compound is a monophosphate, which activates DNA and RNA synthesis. This agent also has antiviral and antifungal effects. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt is synthesized from diphosphate and deoxyribonucleosides. It was first patented in 1979 and has been approved by the US Food and Drug Administration (FDA) for use as a pharmaceutical agent. N-Succinyl-5-aminoimidazole-4-carboxamide ribose disodium salt can be used to produce phosphoramidites, which are synthetic DNA building blocks that are used in the production of DNA and RNA synthesis.

Formula: C₁₃H₁₆N₄O₉Na₂

Purity: Min. 95 Area-%

Color and Shape: Off-White Powder

Molecular weight: 418.27 g/mol

Ref: 3D-NS16860