CAS 173903-47-4

Tizoxanide

Description:

Tizoxanide is an active metabolite of the prodrug nitazoxanide, which is primarily known for its antiparasitic and antiviral properties. It is classified as a thiazolide compound and exhibits a broad spectrum of activity against various pathogens, including protozoa, helminths, and certain viruses. Tizoxanide functions by inhibiting the pyruvate-ferredoxin oxidoreductase enzyme, disrupting energy metabolism in susceptible organisms. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics indicate a relatively long half-life, allowing for once or twice daily dosing in therapeutic regimens. Tizoxanide is generally well-tolerated, with a safety profile that includes mild gastrointestinal side effects. It has been investigated for its potential use in treating infections such as giardiasis, cryptosporidiosis, and even certain viral infections. Ongoing research continues to explore its efficacy and safety in various clinical settings, highlighting its importance in the field of infectious disease treatment.

Formula: C₁₀H₇N₃O₄S

InChI: InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)

InChI key: InChIKey=FDTZUTSGGSRHQF-UHFFFAOYSA-N

SMILES: C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(O)C=CC=C2

Synonyms:

• 2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
• 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
• Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-
• Nsc 697856
• TIZ
• Tizoxanide
• 2-hydroxy-N-(5-nitrothiazol-2-yl)benzaMide

Tizoxanide

CAS: 173903-47-4

Formula: C₁₀H₇N₃O₄S

Purity: >95.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 265.24

Ref: 3B-T3862

Nitazoxanide Related Compound B (2-Hydroxy-N-(5-nitrothiazol-2-yl) benzamide)

CAS: 173903-47-4

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₁₀H₇N₃O₄S

Color and Shape: Pale Yellow Powder

Molecular weight: 265.01573

Ref: 45-1463982

Tizoxanide

CAS: 173903-47-4

Tizoxanide

Formula: C₁₀H₇N₃O₄S

Purity: ≥98%

Molecular weight: 265.25

Ref: 54-BUP06348

Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-

CAS: 173903-47-4

Formula: C₁₀H₇N₃O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 265.2453

Ref: IN-DA001Z9L

Tizoxanide (Nitazoxanide USP Related Compound B)

CAS: 173903-47-4

Formula: C₁₀H₇N₃O₄S

Color and Shape: Pale Brown Solid

Molecular weight: 265.24

Ref: 4Z-T-441

Tizoxanide

CAS: 173903-47-4

Color and Shape: Neat

Ref: 86-MM3279.02

Tizoxanide

CAS: 173903-47-4

2-Hydroxy-N-(5-nitrothiazol-2-yl)benzamide

Formula: C₁₀H₇N₃O₄S

Purity: 98%

Molecular weight: 265.25

Ref: IN-DG208327

Tizoxanide

CAS: 173903-47-4

Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.

Formula: C₁₀H₇N₃O₄S

Purity: 98.89% - 99.28%

Color and Shape: Solid

Molecular weight: 265.25

Ref: TM-T2279

Tizoxanide

CAS: 173903-47-4

Formula: C₁₀H₇N₃O₄S

Molecular weight: 265.24

Ref: ST-EA-CP-T47000

Tizoxanide

Controlled Product

CAS: 173903-47-4

Applications A metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.
References Allen, M., et al.: Hepatology, 27, 1670 (1998), Blight, K., et al.: Science, 290, 1972 (2000), Blight, K., et al.: J. Virol., 77, 3181 (2003), Courcambeck, J., et al.: Antivir Ther., 11, 847 (2006), Hoffman, P., et al.: Antimicrob. Agents Chemother., 51, 868 (2007); de Carvalho et. al., J. Med. Chem., 52, 5789 (2009)

Formula: C₁₀H₇N₃O₄S

Color and Shape: Neat

Molecular weight: 265.25

Ref: TR-T450100

Tizoxanide

CAS: 173903-47-4

Ref: BE-RMCT218001

2-Hydroxy-N-(5-nitro-2-thiazolyl)-benzamide

CAS: 173903-47-4

Formula: C₁₀H₇N₃O₄S

Purity: 90.0%

Color and Shape: Solid

Molecular weight: 265.24

Ref: 10-F044549

Tizoxanide - 98%

CAS: 173903-47-4

Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor

Formula: C₁₀H₇N₃O₄S

Purity: Min. 95%

Molecular weight: 265.01573

Ref: 3D-BT165461

Tizoxanide

CAS: 173903-47-4

Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor

Formula: C₁₀H₇N₃O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 265.25 g/mol

Ref: 3D-FT28294