CAS 17434-18-3

Picropodophyllin

Description:

Picropodophyllin is a naturally occurring compound derived from the plant Podophyllum peltatum, commonly known as the mayapple. It is classified as a lignan and is known for its potential medicinal properties, particularly in the field of oncology. The substance exhibits antitumor activity, primarily by inhibiting the enzyme topoisomerase II, which is crucial for DNA replication and cell division. Picropodophyllin is characterized by its complex molecular structure, which includes multiple aromatic rings and hydroxyl groups, contributing to its biological activity. It is typically found in a crystalline form and is soluble in organic solvents but less so in water. Due to its bioactive properties, research has focused on its potential use in cancer therapies, although further studies are necessary to fully understand its efficacy and safety in clinical applications. As with many natural compounds, the extraction and purification processes can influence its availability and potency, making it a subject of interest in both pharmacognosy and medicinal chemistry.

Formula: C₂₂H₂₂O₈

InChI: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1

InChI key: InChIKey=YJGVMLPVUAXIQN-HAEOHBJNSA-N

SMILES: O=C1[C@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Synonyms:

• Picropodophyllin
• (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Picropodophyllotoxin
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aα,8aα,9α)]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-

Picropodophyllotoxin

CAS: 17434-18-3

Picropodophyllotoxin

Purity: ≥98%

Molecular weight: 414.41g/mol

Ref: 54-BUP05568

Picropodophyllotoxin

CAS: 17434-18-3

Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the

Formula: C₂₂H₂₂O₈

Purity: 99.57%

Color and Shape: Solid

Molecular weight: 414.41

Ref: TM-T3S0027