CAS 1744-22-5: Riluzole

Description: Riluzole is a pharmaceutical compound primarily used in the treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. It is classified as a benzothiazole derivative and functions as a glutamate release inhibitor, which helps to reduce excitotoxicity associated with neuronal damage. Riluzole is typically administered orally and is known for its neuroprotective properties. The substance has a molecular formula that reflects its complex structure, which includes a benzothiazole ring and an alkyl chain. Riluzole is characterized by its moderate solubility in organic solvents and limited solubility in water, which influences its bioavailability and pharmacokinetics. The compound has a relatively low molecular weight and exhibits a half-life that allows for once or twice daily dosing. Side effects may include gastrointestinal disturbances, liver enzyme elevation, and fatigue, necessitating monitoring during treatment. Overall, Riluzole represents a significant advancement in the management of ALS, contributing to prolonged survival and improved quality of life for patients.

Formula: C₈H₅F₃N₂OS

InChI: InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

InChI key: InChIKey=FTALBRSUTCGOEG-UHFFFAOYSA-N

SMILES: FC(F)(F)OC=1C=CC=2N=C(SC2C1)N

Synonyms:

• 1-butyl-3-methyl-1H-imidazol-3-ium hexafluorophosphate
• 2-Amino-6-(trifluoromethoxy)benzothiazole
• 2-Benzothiazolamine, 6-(trifluoromethoxy)-
• 6-(Trifluoromethoxy)-1,3-Benzothiazol-2-Amine
• 6-(Trifluoromethoxy)-1,3-Benzothiazol-2-Amine Hydrochloride
• 6-(Trifluoromethoxy)-1,3-benzothiazol-2-ylamine
• 6-(Trifluoromethoxy)-2-aminobenzothiazole
• 6-(Trifluoromethoxy)-2-benzothiazolamine
• 6-Trifluoromethoxybenzo[d]thiazol-2-amine
• 6-Trifluoromethoxybenzothiazol-2-ylamine
• Benzothiazole, 2-amino-6-(trifluoromethoxy)-
• Bhv 0233
• Pk 26124
• Rilutek
• Rilutor
• Rp 54274

Riluzole

CAS: 1744-22-5

• Formula: C₈H₅F₃N₂OS
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 234.20

2-Amino-6-(trifluoromethoxy)benzothiazole, 98%

CAS: 1744-22-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. …

• Formula: C₈H₅F₃N₂OS
• Purity: 98%
• Molecular weight: 234.2

2-Amino-6-(trifluoromethoxy)benzothiazole

CAS: 1744-22-5

• Purity: 97.0%
• Color and Shape: Solid
• Molecular weight: 234.1999969482422

Riluzole

CAS: 1744-22-5

Compounds containing a benzothiazole ring-system (wheth

• Formula: C₈H₅F₃N₂OS
• Color and Shape: White Light Yellow Powder
• Molecular weight: 234.00747

Riluzole

CAS: 1744-22-5

• Formula: C₈H₅F₃N₂OS
• Color and Shape: White To Off-White Solid
• Molecular weight: 234.20

Riluzole

CAS: 1744-22-5

• Molecular weight: 234.2g/mol

Riluzole

CAS: 1744-22-5

• Formula: C₈H₅F₃N₂OS
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: White powder
• Molecular weight: 234.20

Riluzole

CAS: 1744-22-5

• Formula: C₈H₅F₃N₂OS
• Color and Shape: Neat
• Molecular weight: 234.20

Riluzole, 98%

CAS: 1744-22-5

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Purity: 98%
• Color and Shape: White to yellow, Crystalline powder

2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole

CAS: 1744-22-5

• Formula: C₈H₅F₃N₂OS
• Purity: 97%
• Color and Shape: white powder
• Molecular weight: 234.20g/mol

Riluzole

CAS: 1744-22-5

Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.

• Formula: C₈H₅F₃N₂OS
• Purity: 99.71% - 99.88%
• Color and Shape: Powder
• Molecular weight: 234.2

Riluzole

CAS: 1744-22-5

Applications A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent. …

• Formula: C₈H₅F₃N₂OS
• Color and Shape: Neat
• Molecular weight: 234.20

Riluzole

CAS: 1744-22-5

Glutamate antagonist; activator of TREK-1 and TRAAK K+ channels

• Formula: C₈H₅F₃N₂OS
• Purity: Min. 95 Area-%
• Color and Shape: Powder
• Molecular weight: 234.2 g/mol

Riluzole - Bio-X ™

CAS: 1744-22-5

Riluzole is a glutamate antagonist that is used for the treatment of amyotrophic lateral sclerosis. …

• Formula: C₈H₅F₃N₂OS
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 234.2 g/mol