CAS 1744-22-5

Riluzole

Description:

Riluzole is a pharmaceutical compound primarily used in the treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. It is classified as a benzothiazole derivative and functions as a glutamate release inhibitor, which helps to reduce excitotoxicity associated with neuronal damage. Riluzole is typically administered orally and is known for its neuroprotective properties. The substance has a molecular formula that reflects its complex structure, which includes a benzothiazole ring and an alkyl chain. Riluzole is characterized by its moderate solubility in organic solvents and limited solubility in water, which influences its bioavailability and pharmacokinetics. The compound has a relatively low molecular weight and exhibits a half-life that allows for once or twice daily dosing. Side effects may include gastrointestinal disturbances, liver enzyme elevation, and fatigue, necessitating monitoring during treatment. Overall, Riluzole represents a significant advancement in the management of ALS, contributing to prolonged survival and improved quality of life for patients.

Formula: C₈H₅F₃N₂OS

InChI: InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

InChI key: InChIKey=FTALBRSUTCGOEG-UHFFFAOYSA-N

SMILES: NC1=NC=2C(=CC(OC(F)(F)F)=CC2)S1

Synonyms:

• 1-butyl-3-methyl-1H-imidazol-3-ium hexafluorophosphate
• 2-Amino-6-(trifluoromethoxy)benzothiazole
• 2-Benzothiazolamine, 6-(trifluoromethoxy)-
• 6-(Trifluoromethoxy)-1,3-Benzothiazol-2-Amine
• 6-(Trifluoromethoxy)-1,3-Benzothiazol-2-Amine Hydrochloride
• 6-(Trifluoromethoxy)-1,3-benzothiazol-2-ylamine
• 6-(Trifluoromethoxy)-2-aminobenzothiazole
• 6-(Trifluoromethoxy)-2-benzothiazolamine
• 6-Trifluoromethoxybenzo[d]thiazol-2-amine
• 6-Trifluoromethoxybenzothiazol-2-ylamine
• Benzothiazole, 2-amino-6-(trifluoromethoxy)-
• Bhv 0233
• Pk 26124
• Rilutek
• Rilutor

Riluzole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Purity: >98.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 234.20

Ref: 3B-A2423

2-Amino-6-(trifluoromethoxy)benzothiazole, 98%

CAS: 1744-22-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₅F₃N₂OS

Purity: 98%

Molecular weight: 234.2

Ref: 02-H61328

Riluzole

CAS: 1744-22-5

Compounds containing a benzothiazole ring-system (wheth

Formula: C₈H₅F₃N₂OS

Color and Shape: White Light Yellow Powder

Molecular weight: 234.00747

Ref: 45-1604337

Riluzole

CAS: 1744-22-5

Riluzole

Formula: C₈H₅F₃N₂OS

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 234.2

Ref: 54-BUP17073

Riluzole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Purity: (HPLC) ≥ 98.0%

Color and Shape: White powder

Molecular weight: 234.20

Ref: 7W-GP5490

Riluzole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Color and Shape: White To Off-White Solid

Molecular weight: 234.20

Ref: 4Z-R-141

6-(Trifluoromethoxy)-2-benzothiazolamine

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 234.1983

Ref: IN-DA007UH6

Riluzole

Controlled Product

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Color and Shape: Neat

Molecular weight: 234.2

Ref: 86-MM1382.00

Riluzole

CAS: 1744-22-5

Applications A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)

Formula: C₈H₅F₃N₂OS

Color and Shape: Neat

Molecular weight: 234.2

Ref: TR-R510000

Riluzole

CAS: 1744-22-5

6-(Trifluoromethoxy)benzo[d]thiazol-2-amine

Formula: C₈H₅F₃N₂OS

Purity: 97%

Molecular weight: 234.2

Ref: IN-DG18886

2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole

CAS: 1744-22-5

2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole

Formula: C₈H₅F₃N₂OS

Purity: 97%

Color and Shape: White Solid

Molecular weight: 234.1983

Ref: 54-PC1100C

Riluzole

CAS: 1744-22-5

Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.

Formula: C₈H₅F₃N₂OS

Purity: 99.6% - 99.88%

Color and Shape: Solid

Molecular weight: 234.198

Ref: TM-T0349

Riluzole - Bio-X ™

CAS: 1744-22-5

Riluzole is a glutamate antagonist that is used for the treatment of amyotrophic lateral sclerosis. This drug is also used as an anticonvulsant. Although a complete mechanism of action is unknown, it has an inhibitory effect on glutamate release and it inactivates voltage dependent sodium channels.

Formula: C₈H₅F₃N₂OS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 234.2 g/mol

Ref: 3D-BR164340

Riluzole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Color and Shape: Solid

Molecular weight: 234.2

Ref: BE-RMCR081000

2-Amino-6-(trifluoromethoxy)benzothiazole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Purity: 97%

Color and Shape: Solid

Molecular weight: 234.2

Ref: 10-F004026

Riluzole

CAS: 1744-22-5

Formula: C₈H₅F₃N₂OS

Molecular weight: 234.2o

Ref: ST-EA-CP-R14000

Riluzole

CAS: 1744-22-5

Glutamate antagonist; activator of TREK-1 and TRAAK K+ channels

Formula: C₈H₅F₃N₂OS

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 234.2 g/mol

Ref: 3D-FR27733