CAS 174484-41-4

Tipranavir

Description:

Tipranavir is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of protease inhibitors and is often administered in combination with other antiretroviral agents to enhance its efficacy. The chemical formula of tipranavir is C25H34N2O4S, and it features a sulfonamide group, which contributes to its mechanism of action by inhibiting the HIV protease enzyme, thereby preventing viral replication. Tipranavir is characterized by its relatively high lipophilicity, which influences its absorption and distribution in the body. It is typically available in oral formulations, and its pharmacokinetics can be affected by factors such as food intake and co-administration with other drugs. Common side effects may include gastrointestinal disturbances, rash, and potential liver enzyme elevation. Due to its unique structure and mechanism, tipranavir is particularly valuable in treatment-experienced patients who may have developed resistance to other protease inhibitors. Regular monitoring and adherence to prescribed regimens are essential for optimizing treatment outcomes.

Formula: C₃₁H₃₃F₃N₂O₅S

InChI: InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1

InChI key: InChIKey=SUJUHGSWHZTSEU-FYBSXPHGSA-N

SMILES: C(CC1=CC=CC=C1)[C@]2(CCC)CC(O)=C([C@H](CC)C3=CC(NS(=O)(=O)C4=CC=C(C(F)(F)F)C=N4)=CC=C3)C(=O)O2

Synonyms:

• 2-Pyridinesulfonamide, N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-, [R-(R*,R*)]-
• U 140690
• PNU-140690
• N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
• Aptivus
• N-[3-[(1R)-1-[(6R)-2-Hydroxy-4-oxo-6-phenethyl-6-propyl-5H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
• PNU 140690
• N-[3-[(1R)-1-[(6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide
• N-(3-{(1R)-1-[(2R)-6-hydroxy-4-oxo-2-(2-phenylethyl)-2-propyl-3,4-dihydro-2H-pyran-5-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
• N-[3-[(1R)-1-[(6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide
• 2-Pyridinesulfonamide, N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-

2-Pyridinesulfonamide, N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-

CAS: 174484-41-4

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 602.6643

Ref: IN-DA001ZOJ

Tipranavir

CAS: 174484-41-4

Tipranavir

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: ≥98%, 10 mM in DMSO

Molecular weight: 602.66

Ref: 54-BUP04299

Tipranavir

CAS: 174484-41-4

Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: 99.85%

Color and Shape: White Solid

Molecular weight: 602.66

Ref: TM-T4578

Tipranavir

CAS: 174484-41-4

Formula: C₃₁H₃₃F₃N₂O₅S

Color and Shape: White To Off-White Solid

Molecular weight: 602.67

Ref: 4Z-T-115001

Tipranavir

CAS: 174484-41-4

Tipranavir

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: 98%

Molecular weight: 602.66

Ref: IN-DG154215

Tipranavir

CAS: 174484-41-4

Applications Nonpeptidic HIV protease inhibitor (NPPI). Antiviral.
References Poppe, S.M., et al.: Antimicrob. Agents Chemother., 41, 1058 (1997), McGregor, T.R., et al.: HIV Clin. Trials, 5, 371 (2004), Boffito, M., et al.: J. Clin. Pharmacol., 46, 130 (2006),

Formula: C₃₁H₃₃F₃N₂O₅S

Color and Shape: Neat

Molecular weight: 602.66

Ref: TR-T444900

Tipranavir - Bio-X ™

CAS: 174484-41-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 602.67 g/mol

Ref: 3D-BT300133

Tipranavir

CAS: 174484-41-4

Antiviral; nonpeptidic HIV-1 protease inhibitor

Formula: C₃₁H₃₃F₃N₂O₅S

Purity: (%) Min. 98%

Color and Shape: White Powder

Molecular weight: 602.67 g/mol

Ref: 3D-FT28290

N-{3-[(1S)-1-[(6R)-2,4-dioxo-6-(2-phenylethyl)-6-propyloxan-3-yl]propyl]phenyl}-5-(trifluoromethyl)pyridine-2-sulfonamide

CAS: 174484-41-4

Purity: 98%

Molecular weight: 602.6699829

Ref: 10-F862026