CAS 174838-79-0

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH

Description:

The chemical substance known as Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH, with the CAS number 174838-79-0, is a synthetic peptide that features a sequence of amino acids. This peptide is characterized by its incorporation of both standard amino acids and a modified amino acid, m-nitro-Tyrosine, which introduces unique properties such as increased hydrophobicity and potential for enhanced biological activity. The presence of multiple basic residues, such as arginine and lysine, suggests that the peptide may exhibit strong interactions with negatively charged molecules, which can be relevant in biological systems. Additionally, the peptide's structure may influence its solubility, stability, and interaction with receptors or enzymes. Peptides like this one are often studied for their potential applications in drug development, particularly in targeting specific biological pathways or as tools in biochemical research. Overall, the characteristics of this peptide make it a subject of interest in both medicinal chemistry and biochemistry.

Formula: C₅₄H₈₄N₁₈O₁₆

Synonyms:

• H-2-Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-3-Nitro-Tyr-Asp-Oh
• Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(No2)-Asp

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH

CAS: 174838-79-0

Internally quenched fluorogenic peptide substrate containing anthranilic acid as fluorescent donor and m-nitro-tyrosine as acceptor (quencher). The sequence Abz-RVKRGLAY(NO₂)E is based on the sequence of hemagglutinin. The FRET substrate is efficiently cleaved by furin, a subtilisin-like eukaryotic serine endoprotease with Km = 3.8 µM and kcat = 29.3 s-¹ (kcat/Km = 7’710’000 M-¹s-¹). Its kcat/Km value is over 2000-fold higher than that of the commonly used substrate Boc-Arg-Val-Arg-Arg-AMC (I-1645). FRET Substrate for the basic residue-specific yeast aspartyl protease yapsin 1.

Formula: C₅₄H₈₄N₁₈O₁₆

Purity: 94.5%

Color and Shape: Yellow Powder

Molecular weight: 1241.37

Ref: 01-4026550

L-Aspartic acid, N-[N-[N-[N-[N-[N2-[N2-[N-[N2-(2-aminobenzoyl)-L-arginyl]-L-valyl]-L-lysyl]-L-arginyl]glycyl]-L-leucyl]-L-alanyl]-3-nitro-L-tyrosyl]- (9CI)

CAS: 174838-79-0

Formula: C₅₄H₈₄N₁₈O₁₆

Molecular weight: 1241.3558

Ref: IN-DA001ZZD

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH trifluoroacetate salt

CAS: 174838-79-0

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH trifluoroacetate salt (ABZKAA) is a small molecule that inhibits the influenza virus by binding to the receptor binding domain of the hemagglutinin protein. ABZKAA has been shown to inhibit atherosclerotic lesion growth in mice, and also binds to activated carboxy terminal sites on proteins, which are involved in many cellular processes such as cell growth and apoptosis. This drug has been shown to have toxicity profiles with no apparent side effects in animal studies and is not toxic for healthy cells. ABZKAA binds to proteases such as furin and actin filaments, which are enzyme substrates involved in protein synthesis. It also inhibits viral replication by inhibiting viral protease activity.br>br>ABZKAA is being developed as an inhibitor of

Formula: C₅₄H₈₄N₁₈O₁₆

Purity: Min. 95%

Molecular weight: 1,241.36 g/mol

Ref: 3D-FA110917