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CAS 176161-24-3

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Maribavir

Description:
Maribavir is an antiviral compound primarily investigated for its efficacy against cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those undergoing organ transplantation or with HIV/AIDS. It belongs to the class of compounds known as benzimidazoles and functions by inhibiting the viral replication process. Maribavir exhibits a unique mechanism of action by targeting the viral UL97 kinase, which is crucial for CMV replication and maturation. The substance is characterized by its moderate solubility in water and stability under various pH conditions, making it suitable for oral administration. In clinical studies, Maribavir has shown a favorable safety profile, with common side effects being generally mild. Its development represents a significant advancement in antiviral therapy, particularly for patients who are resistant to other treatments. As research continues, Maribavir's potential applications may expand, contributing to the broader field of antiviral drug development.
Formula:C15H19Cl2N3O4
InChI:InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
InChI key:InChIKey=KJFBVJALEQWJBS-XUXIUFHCSA-N
SMILES:N(C(C)C)C=1N(C=2C(N1)=CC(Cl)=C(Cl)C2)[C@H]3O[C@@H](CO)[C@H](O)[C@@H]3O
Synonyms:
  • 1263W94
  • 1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-<span class="text-smallcaps">L</span>-ribofuranosyl-
  • 5,6-Dichloro-2-(Isopropylamino)-1-(Beta-L-Ribofuranosyl)-1H-Benzimidazole
  • 5,6-Dichloro-2-Isopropylamino-1-(-L-Ribofuranosyl)-Lh-Benzimidazole
  • 5,6-Dichloro-N-(1-methylethyl)-1-β-<span class="text-smallcaps">L</span>-ribofuranosyl-1H-benzimidazol-2-amine
  • 5,6-dichloro-1-[(1S)-pentofuranosyl]-N-(propan-2-yl)-1H-benzimidazol-2-amine
  • 5,6-dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine
  • BENZIMIDAVIR, 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
  • Benzimidavir: 5,6-Dichloro-2-(Isopropylamino)-1-(Ss-L-Ribofuranosyl)-Lh-Benzimidazole
  • Bw 1263W94
  • See more synonyms
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