CAS 1792214-00-6

Formula: C25H29F2N9O3

InChI: InChI=1S/C25H29F2N9O3/c26-16-9-30-23-20(22(28)32-36(23)12-16)24(37)31-19-11-29-10-18(27)21(19)34-3-1-15(2-4-34)25(38)35-7-5-33(6-8-35)17-13-39-14-17/h9-12,15,17H,1-8,13-14H2,(H2,28,32)(H,31,37)/i5D2,6D2,7D2,8D2

InChI key: QAYHKBLKSXWOEO-YEBVBAJPSA-N

SMILES: [2H]C1(C(N(C(C(N1C2COC2)([2H])[2H])([2H])[2H])C(=O)C3CCN(CC3)C4=C(C=NC=C4NC(=O)C5=C6N=CC(=CN6N=C5N)F)F)([2H])[2H])[2H]

Gartisertib-d8

CAS: 1792214-00-6

Gartisertib-d8 (VX-803-d8) is the deuterated form of Gartisertib. Gartisertib (VX-803) acts as an orally active, selective ATP-competitive ATR inhibitor, with a Ki of less than 150 pM. It effectively inhibits ATR-driven phosphorylation of checkpoint kinase-1 (Chk1), with an IC50 value of 8 nM, and exhibits antitumor activity.

Formula: C₂₅H₂₉F₂N₉O₃

Molecular weight: 549.61

Ref: TM-TMIT-0483

Gartisertib-d8

CAS: 1792214-00-6

Formula: C₂₅H₂₁D₈F₂N₉O₃

Molecular weight: 549.6

Ref: TR-A523361