CAS 1792999-26-8

cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

CAS: 1792999-26-8

Formula: C₂₁H₂₁N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 375.4237

Ref: IN-DA01E2UJ

Cis-4-((2-((1H-Benzo[D]Imidazol-6-Yl)Amino)Quinazolin-8-Yl)Oxy)Cyclohexanol

CAS: 1792999-26-8

Cis-4-((2-((1H-Benzo[D]Imidazol-6-Yl)Amino)Quinazolin-8-Yl)Oxy)Cyclohexanol

Purity: 99%

Molecular weight: 375.42g/mol

Ref: 54-OR1023980

NCB-0846

CAS: 1792999-26-8

NCB-0846

Purity: ≥95%

Molecular weight: 375.42g/mol

Ref: 54-BUP05371

NCB-0846

CAS: 1792999-26-8

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

Formula: C₂₁H₂₁N₅O₂

Purity: 97.04% - 99.89%

Color and Shape: Solid

Molecular weight: 375.42

Ref: TM-T4011

cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol

Controlled Product

CAS: 1792999-26-8

Applications cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.
References Masuda, M., et al.: Nat Commun. 7, 12586 (2016); Masuda, M., et al.: Pharmacol. Ther. 156, 1 (2017);

Formula: C₂₁H₂₁N₅O₂

Color and Shape: Neat

Molecular weight: 375.42

Ref: TR-B197005

cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

CAS: 1792999-26-8

Cis-4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol is a ligand that binds to the coxsackievirus and adenovirus receptor (CovR) and blocks its function. The CovR protein is expressed on the surface of cells in the heart, lungs, and other tissues. Cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol is a temporary antiviral agent that has been synthesized to evaluate its potential as an antiviral drug for use during a pandemic. The synthesized compound has been evaluated by analytical methods such as NMR and mass spectroscopy. These evaluations have shown that cis-4-[2-(1H benzimidazol 6 ylamino)-8 quinazolinyl]

Formula: C₂₁H₂₁N₅O₂

Purity: Min. 95%

Molecular weight: 375.42 g/mol

Ref: 3D-SWC99926