CAS 179324-22-2

Z-Leu-Leu-Leu-B(OH)2 (MG262)

Description:

Z-Leu-Leu-Leu-B(OH)2, also known as MG262, is a synthetic peptide compound characterized by its structure, which includes a boronic acid moiety. This compound is primarily recognized for its role as a proteasome inhibitor, which is significant in cancer research and treatment. The presence of the boronic acid group allows it to interact with the active site of the proteasome, thereby disrupting protein degradation pathways that are crucial for cellular homeostasis. MG262 has been studied for its potential therapeutic applications, particularly in hematological malignancies and solid tumors, as it can induce apoptosis in cancer cells by preventing the breakdown of pro-apoptotic factors. Additionally, its peptide nature contributes to its specificity and potency in targeting proteasomal activity. The compound is typically administered in research settings, and its effects are evaluated through various biochemical assays to understand its mechanism of action and therapeutic potential. Overall, Z-Leu-Leu-Leu-B(OH)2 represents a valuable tool in the exploration of proteasome inhibition and its implications in cancer biology.

Formula: C₂₅H₄₂BN₃O₆

Synonyms:

• L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-borono-3-methylbutyl]-
• [(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid
• Proteasome Inhibitor III - Calbiochem
• Z-Leu-Leu-Leu-B(OH)2 (MG262)

Z-Leu-Leu-Leu-B(OH)2

CAS: 179324-22-2

Formula: C₂₅H₄₂BN₃O₆

Molecular weight: 491.4

Ref: 7W-GL0498

Proteasome Inhibitor III

CAS: 179324-22-2

Proteasome Inhibitor III (PI3) is a natural compound that has been shown to have cytotoxic activity against tumor cells. PI3 inhibits the protease activity of the 26S proteasome, which leads to the accumulation of oxidized proteins and DNA damage. PI3 also induces autophagy and mitophagy, which are cellular processes that help protect against oxidative injury. PI3 also interferes with signal pathways such as the p38/JNK pathway and the STAT-3 pathway, leading to increased levels of c-jun phosphorylation and colony-stimulating factor (CSF), respectively. PI3 is also able to inhibit k562 cells proliferation in vitro by blocking cell cycle progression at G2/M phase. The molecular pathogenesis of prostate cancer is not well understood; however, it may be due in part to increased levels of reactive oxygen species within mitochondria.

Formula: C₂₅H₄₂BN₃O₆

Purity: Min. 95%

Molecular weight: 491.43 g/mol

Ref: 3D-EHA32422

MG-262

CAS: 179324-22-2

MG-262 is a reversible proteasome inhibitor with multiple biological activities [1] [2] [3].

Formula: C₂₅H₄₂BN₃O₆

Color and Shape: Solid

Molecular weight: 491.43

Ref: TM-T21968