CAS 179324-69-7: Bortezomib

Description: Bortezomib is a proteasome inhibitor primarily used in the treatment of multiple myeloma and certain types of lymphoma. It is a synthetic compound that belongs to the class of boronic acid derivatives. The chemical formula of Bortezomib is C19H25BoroN4O4, and it features a boron atom that plays a crucial role in its mechanism of action, which involves the inhibition of the proteasome, a cellular complex responsible for degrading ubiquitinated proteins. This inhibition leads to the accumulation of pro-apoptotic factors and cell cycle regulators, ultimately inducing apoptosis in cancer cells. Bortezomib is administered via intravenous or subcutaneous injection and is known for its side effects, which may include peripheral neuropathy, gastrointestinal issues, and hematological toxicities. Its pharmacokinetics involve rapid absorption and distribution, with a half-life that allows for effective dosing schedules. Overall, Bortezomib represents a significant advancement in targeted cancer therapy, showcasing the potential of small molecules in the treatment of hematological malignancies.

Formula: C₁₉H₂₅BN₄O₄

InChI: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

InChI key: InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N

SMILES: O=C(NC(C(=O)NC(B(O)O)CC(C)C)CC=1C=CC=CC1)C2=NC=CN=C2

Synonyms:

• B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
• Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-
• Boronic acid, [3-methyl-1-[[1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-, [S-(R*,S*)]-
• Bortezomib for research
• Bortizomib
• Brotezamide
• Dpba
• Ldp 341
• Mg 341
• Mln 341
• N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
• N-[(1S)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-D-phenylalaninamide
• NSC 681239
• PS 341 (pharmaceutical)
• Ps 314
• Ps 341
• Radiciol
• Velcade
• [(1R)-3-Methyl-1-[[(2S)-1-Oxo-3-Phenyl-2-[(Pyrazinylcarbonyl)Amino]Propyl]Amino]Butyl]-Boronic Acid

Bortezomib, 98%

CAS: 179324-69-7

A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as …

• Formula: C₁₉H₂₅BN₄O₄
• Purity: 98%
• Color and Shape: Powder or crystals or crystalline powder, White to off-white
• Molecular weight: 384.24

Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-

CAS: 179324-69-7

• Formula: C₁₉H₂₅BN₄O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 384.2372

Bortezomib

CAS: 179324-69-7

• Purity: 99.97%
• Molecular weight: 384.24g/mol

Bortezomib

CAS: 179324-69-7

• Formula: C₁₉H₂₅BN₄O₄
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder or solid
• Molecular weight: 384.24

Bortezomib

CAS: 179324-69-7

• Formula: C₁₉H₂₅BN₄O₄
• Purity: 98% (nmr) (Typical Value in Batch COA)
• Color and Shape: white solid
• Molecular weight: 384.24g/mol

Bortezomib

CAS: 179324-69-7

• Formula: C₁₉H₂₅BN₄O₄
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 384.24

Bortezomib

CAS: 179324-69-7

Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.

• Formula: C₁₉H₂₅BN₄O₄
• Purity: 100% - 99.97%
• Color and Shape: Yellow Solid
• Molecular weight: 384.24

(1R,2S)-Bortezomib

CAS: 179324-69-7

• Formula: C₁₉H₂₅BN₄O₄
• Molecular weight: 384.24

Bortezomib

CAS: 179324-69-7

Stability Hygroscopic and Moisture Sensitive Applications Bortezomib is the first proteasome inhibitor to be approved …

• Formula: C₁₉H₂₅BN₄O₄
• Color and Shape: White To Off-White
• Molecular weight: 384.24

Bortezomib-D8 (Major)

CAS: 179324-69-7

Applications Labelled Bortezomib, which the first proteasome inhibitor to be approved by the US FDA …

• Formula: C₁₉H₁₇D₈BN₄O₄
• Color and Shape: Off-White
• Molecular weight: 392.29

Bortezomib

CAS: 179324-69-7

Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects …

• Formula: C₁₉H₂₅BN₄O₄
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 384.24 g/mol

Bortezomib - Bio-X ™

CAS: 179324-69-7

Bortezomib is a selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of …

• Formula: C₁₉H₂₅BN₄O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 384.24 g/mol