CAS 179474-81-8
:Prucalopride
Description:
Prucalopride is a selective serotonin receptor agonist, primarily targeting the 5-HT4 receptor subtype, which plays a crucial role in gastrointestinal motility. It is primarily used as a prokinetic agent for the treatment of chronic constipation, particularly in patients who have not responded adequately to other laxatives. The chemical formula of prucalopride is C18H24N2O3S, and it has a molecular weight of approximately 348.46 g/mol. This compound is characterized by its ability to enhance colonic peristalsis, thereby facilitating bowel movements. Prucalopride is administered orally and is known for its favorable safety profile, with a lower incidence of side effects compared to older prokinetic agents. Its pharmacokinetics include good oral bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, prucalopride is not significantly metabolized by the liver, which reduces the potential for drug-drug interactions. Overall, prucalopride represents a targeted approach to managing constipation, improving the quality of life for affected individuals.
Formula:C18H26ClN3O3
InChI:InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChI key:InChIKey=ZPMNHBXQOOVQJL-UHFFFAOYSA-N
SMILES:C(NC1CCN(CCCOC)CC1)(=O)C2=C3C(=C(N)C(Cl)=C2)CCO3
Synonyms:- 7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-
- 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
- Prucalopride
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Found 12 products.
Prucalopride
CAS:Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.Formula:C18H26ClN3O3Purity:99.99% - >99.99%Color and Shape:SolidMolecular weight:367.874-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
CAS:Formula:C18H26ClN3O3Purity:98%Color and Shape:SolidMolecular weight:367.8703Prucalopride
CAS:Formula:C18H26ClN3O3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:367.874-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
CAS:The drug 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (BZP) is a histamine H2 receptor antagonist. It binds to the histamine H2 receptor in the stomach and duodenum, thereby blocking stomach acid production. BZP has been shown to be effective for treating symptoms of constipation or diarrhoea caused by inflammatory bowel disease or abdominal surgery. BZP also reduces the risk of relapse after surgery but does not affect long term efficacy. This drug is not available in the United States and has significant interactions with other drugs and symptoms including constipation, bowel disease, long term efficacy, and analytical method.Formula:C18H26ClN3O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:367.87 g/molPrucalopride-d5
CAS:Controlled ProductFormula:C18D5H21ClN3O3Color and Shape:NeatMolecular weight:372.901
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