CAS 1797989-42-4

CHIR-99021 HCl

CAS: 1797989-42-4

CHIR-99021 HCl

Purity: ≥98%

Molecular weight: 501.8g/mol

Ref: 54-BUP15221

CHIR-99021 monohydrochloride

CAS: 1797989-42-4

CHIR-99021 monohydrochloride

Purity: 98%

Molecular weight: 501.8g/mol

Ref: 54-OR1026201

6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile hydrochloride

CAS: 1797989-42-4

Purity: 98%

Molecular weight: 501.7999878

Ref: 10-F870350

CHIR-99021 Hydrochloride

CAS: 1797989-42-4

Applications CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3α/β inhibitor
References Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);

Formula: C₂₂H₁₉Cl₃N₈

Color and Shape: Neat

Molecular weight: 501.8

Ref: TR-C292150

CHIR 99021 hydrochloride

CAS: 1797989-42-4

Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.

Formula: C₂₂H₁₈Cl₂N₈·HCl

Purity: Min. 95%

Molecular weight: 501.8 g/mol

Ref: 3D-BC162488

CHIR-99021 HCl

CAS: 1797989-42-4

CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.

Formula: C₂₂H₁₉Cl₃N₈

Purity: 98.07% - 98.14%

Color and Shape: Solid

Molecular weight: 501.8

Ref: TM-T2310L