CAS 18037-10-0

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine

Description:

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine, with CAS number 18037-10-0, is a chemical compound characterized by its unique structure that includes a pyrimidine ring substituted with trimethylsilyl groups. This compound typically exhibits properties associated with both organic and organosilicon chemistry, including enhanced stability and solubility in organic solvents due to the presence of the trimethylsilyl groups. The trimethylsilyl moieties can also influence the compound's reactivity, making it useful in various synthetic applications, particularly in the field of organic synthesis and as a protecting group in chemical reactions. Additionally, the presence of the amino group in the pyrimidine structure may impart basicity and potential for hydrogen bonding, which can affect its interactions in biological systems. Overall, this compound is of interest in both academic research and industrial applications, particularly in the development of pharmaceuticals and agrochemicals.

Formula: C₁₀H₂₁N₃OSi₂

InChI: InChI=1S/C10H21N3OSi2/c1-15(2,3)13-9-7-8-11-10(12-9)14-16(4,5)6/h7-8H,1-6H3,(H,11,12,13)

InChI key: InChIKey=IWEHUWMQLZFGLL-UHFFFAOYSA-N

SMILES: N([Si](C)(C)C)C1=NC(O[Si](C)(C)C)=NC=C1

Synonyms:

• 1,1,1-Trimethyl-N-[2-[(trimethylsilyl)oxy]pyrimidin-4-yl]silanamine
• 2,4-Bis(trimethylsilyl)cytosine
• 4-Pyrimidinamine, N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]-
• Bis(Trimethylsilyl)Cytosine
• Bistrimethylsilylcytosine
• N-(Trimethylsilyl)-2-[(Trimethylsilyl)Oxy]-4-Pyrimidinamin
• N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine
• N-(trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
• O,N-Bis(trimethylsilyl)cytosine
• O2,N4-Bis(trimethylsilyl)cytosine
• Pyrimidine, 2-(trimethylsiloxy)-4-[(trimethylsilyl)amino]-

N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]-4-pyrimidinamine

CAS: 18037-10-0

Formula: C₁₀H₂₁N₃OSi₂

Color and Shape: Solid

Molecular weight: 255.4642

Ref: IN-DA0021YC

Bis(trimethylsilyl)cytosine

CAS: 18037-10-0

Bis(trimethylsilyl)cytosine is an immunosuppressive agent that binds to the immunodeficient acceptor. It has been shown to be active against a number of viruses, including HIV-1 and HSV-1. Bis(trimethylsilyl)cytosine also inhibits the activity of purine and pyrimidine nucleotide synthesis, although it does not inhibit the activity of adenosine deaminase or ribonucleotide reductase. This compound has been shown to stimulate the immune system in mice with a deficiency in T cells by reducing the expression of genes that are responsible for cytokines such as IL-4 and IL-10.

Formula: C₁₀H₂₁N₃OSi₂

Purity: Min. 90%

Color and Shape: Powder

Molecular weight: 255.46 g/mol

Ref: 3D-FB149469

2,4-Bis(trimethylsilyl)cytosine

Controlled Product

CAS: 18037-10-0

Applications 2,4-Bis(trimethylsilyl)cytosine is an intermediate used in the synthesis of 1’-Epi Gemcitabine Hydrochloride (E588510), which is an α-Anomer of Gemcitabine.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Formula: C₁₀H₂₁N₃OSi₂

Color and Shape: Neat

Molecular weight: 255.464

Ref: TR-B101910