CAS 1813527-81-9

Formula: C26H22FN7O3

InChI: InChI=1S/C26H22FN7O3/c1-14-22(25(36)32-17-6-8-21-16(10-17)12-30-34-21)23(33-26(37)31-14)15-5-7-20(27)19(11-15)24(35)29-13-18-4-2-3-9-28-18/h2-12,23H,13H2,1H3,(H,29,35)(H,30,34)(H,32,36)(H2,31,33,37)

InChI key: BLMBNKDQXGINRE-UHFFFAOYSA-N

SMILES: CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=CC=CC=N3)C(=O)NC4=CC5=C(C=C4)NN=C5

CCG215022

CAS: 1813527-81-9

CCG215022

Formula: C₂₆H₂₂FN₇O₃

Purity: 97.5%

Molecular weight: 499.5

Ref: 54-BUP07370

4-[4-Fluoro-3-[[(2-pyridinylmethyl)amino]carbonyl]phenyl]-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide

CAS: 1813527-81-9

Formula: C₂₆H₂₂FN₇O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 499.4964

Ref: IN-DA00ABR7

CCG215022

CAS: 1813527-81-9

CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.

Formula: C₂₆H₂₂FN₇O₃

Purity: 97.63% - 99.69%

Color and Shape: Solid

Molecular weight: 499.4964

Ref: TM-T3498

CCG215022

CAS: 1813527-81-9

4-(4-Fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Formula: C₂₆H₂₂FN₇O₃

Purity: 99%

Molecular weight: 499.5

Ref: IN-DG764795

CCG215022

CAS: 1813527-81-9

CCG215022 is a small-molecule inhibitor of GSK3β. It has been shown to induce death in cancer cells that are resistant to other chemotherapies, such as rhabdomyosarcoma, and is effective at inhibiting the growth of various cancers, including breast cancer. CCG215022 binds to the ATP-binding pocket of GSK3β and inhibits its activity by preventing the formation of phosphorylated peptides on kinase domain. The inhibition of this enzyme leads to increased contractility and increased hydrophobicity, which may be responsible for its effect on cancer cells. CCG215022 also has an excellent safety profile in pediatric patients and is effective at doses that are lower than those required for adults.

Formula: C₂₆H₂₂FN₇O₃

Purity: Min. 95%

Molecular weight: 499.5 g/mol

Ref: 3D-NXC52781