CAS 183319-69-9: Erlotinib hydrochloride
Description:Erlotinib hydrochloride is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer and pancreatic cancer. It specifically targets the epidermal growth factor receptor (EGFR), inhibiting its activity and thereby blocking the signaling pathways that promote tumor growth and survival. The compound is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective for certain brain metastases. Erlotinib hydrochloride is characterized by its solubility in water due to the presence of the hydrochloride salt, which enhances its bioavailability. The molecular formula reflects its complex structure, which includes a quinazoline core. Common side effects associated with its use include skin rash, diarrhea, and potential liver enzyme elevation. As with many targeted therapies, the effectiveness of erlotinib can be influenced by the presence of specific mutations in the EGFR gene, making genetic testing an important consideration in treatment planning. Overall, erlotinib hydrochloride represents a significant advancement in personalized cancer therapy.
Formula:C22H23N3O4·ClH
InChI:InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChI key:InChIKey=GTTBEUCJPZQMDZ-UHFFFAOYSA-N
SMILES:Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32
- Synonyms:
- 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)
- 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride
- 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
- Cp 358774
- Erlotinib HCl
- Erlotinib Hcl Salt
- Erlotinib, Hydrochloride Salt
- Erlotinib, OS-774
- N-(2-chloro-6-methyl-phenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methyl-pyrimidin-4-yl]amino]thiazole-5-carboxamide
- N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride
- See more synonyms
- N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine Hydrochloride
- N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
- N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
- N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
- N-(4-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
- Osi 774
- Tarceva
- [6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
- [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
- quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
- Tarceva Hydrochloride See E625000
