CAS 183319-69-9: Erlotinib hydrochloride

Description: Erlotinib hydrochloride is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer and pancreatic cancer. It specifically targets the epidermal growth factor receptor (EGFR), inhibiting its activity and thereby blocking the signaling pathways that promote tumor growth and survival. The compound is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective for certain brain metastases. Erlotinib hydrochloride is characterized by its solubility in water due to the presence of the hydrochloride salt, which enhances its bioavailability. The molecular formula reflects its complex structure, which includes a quinazoline core. Common side effects associated with its use include skin rash, diarrhea, and potential liver enzyme elevation. As with many targeted therapies, the effectiveness of erlotinib can be influenced by the presence of specific mutations in the EGFR gene, making genetic testing an important consideration in treatment planning. Overall, erlotinib hydrochloride represents a significant advancement in personalized cancer therapy.

Formula: C₂₂H₂₃N₃O₄·ClH

InChI: InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChI key: InChIKey=GTTBEUCJPZQMDZ-UHFFFAOYSA-N

SMILES: Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32

Synonyms:

• 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)
• 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride
• 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
• Cp 358774
• Erlotinib HCl
• Erlotinib Hcl Salt
• Erlotinib, Hydrochloride Salt
• Erlotinib, OS-774
• N-(2-chloro-6-methyl-phenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methyl-pyrimidin-4-yl]amino]thiazole-5-carboxamide
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride
• N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine Hydrochloride
• N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
• N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
• N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
• N-(4-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1)
• Osi 774
• Tarceva
• [6,7-Bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
• [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
• quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
• Tarceva Hydrochloride See E625000
• Erlotinib HCl(TINIBS)
• Erlotinib hydrochloride
• ERLOTINIB
• 6,7-BIS(2-METHOXYETHOXY)-4-(3-ETHYNYLANILINO)QUINAZOLINE HCL
• ERLOTINIB HCL SALT :TARCEVA
• erlotinib hydorchloride
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
• 21 Erlotinib hydrochloride and Intermediate
• Tarceva HydrochlorideSee E625000
• Erlotonid HCl
• 6,7-Bis(2-methoxyethoxy)-4-(3-

Erlotinib Hydrochloride

CAS: 183319-69-9

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Formula: C₂₂H₂₃N₃O₄·HCl
• Color and Shape: Pale Yellow Powder
• Molecular weight: 429.14553

Erlotinib hydrochloride

CAS: 183319-69-9

Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for …

• Formula: C₂₂H₂₃N₃O₄·HCl
• Purity: 99.78% - 99.85%
• Color and Shape: White Or Off-White Powder
• Molecular weight: 429.9

4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1)

CAS: 183319-69-9

• Formula: C₂₂H₂₄ClN₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 429.89666000000005

Erlotinib Hydrochloride Salt

CAS: 183319-69-9

• Formula: C₂₂H₂₃N₃O₄·ClH
• Purity: By hplc: 99.9% by area (Typical Value in Batch COA)
• Color and Shape: white to off-white crystalline solid
• Molecular weight: 429.90g/mol

Erlotinib hydrochloride

CAS: 183319-69-9

• Purity: ≥98%
• Molecular weight: 429.9g/mol

Erlotinib hydrochloride

CAS: 183319-69-9

• Formula: C₂₂H₂₃N₃O₄·HCl
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white powder
• Molecular weight: 429.90

Erlotinib HCl

CAS: 183319-69-9

• Formula: C₂₂H₂₃N₃O₄·HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 393.45 36.46

Erlotinib Hydrochloride

CAS: 183319-69-9

• Formula: C₂₂H₂₃N₃O₄·ClH
• Color and Shape: Neat
• Molecular weight: 429.90

Erlotinib Hydrochloride

CAS: 183319-69-9

• Formula: C₂₂H₂₃N₃O₄·HCl
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 429.90

Erlotinib Impurity 95

CAS: 183319-69-9

• Formula: C₁₄H₈ClN₃O₂
• Molecular weight: 285.69

Erlotinib Hydrochloride (Tarceva)

CAS: 183319-69-9

Applications Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic. References Moyer, J.D., et al.: …

• Formula: C₂₂H₂₃N₃O₄·ClH
• Color and Shape: White To Light Yellow
• Molecular weight: 429.90

Erlotinib hydrochloride

CAS: 183319-69-9

• Purity: 97.0%
• Color and Shape: Solid, Crystalline Powder
• Molecular weight: 429.899993896484

Tarceva (Erlotinib Hydrochloride)

CAS: 183319-69-9

Applications Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic. References Moyer, J.D., et al.: …

• Formula: C₂₂H₂₃N₃O₄·ClH
• Color and Shape: Neat
• Molecular weight: 429.90

Erlotinib hydrochloride - Bio-X ™

CAS: 183319-69-9

Erlotinib is a drug that is used to treat human malignancies. It is a type …

• Formula: C₂₂H₂₃N₃O₄·HCl
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 429.9 g/mol

Erlotinib HCl

CAS: 183319-69-9

Tyrosine kinase inhibitor; affects EGFR receptor; pancreatic cancer treatment

• Formula: C₂₂H₂₃N₃O₄·HCl
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 429.9 g/mol

Erlotinib hydrochloride

CAS: 183319-69-9

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₂H₂₄ClN₃O₄
• Color and Shape: White to yellow, Powder
• Molecular weight: 429.90