CAS 185039-89-8

PD0166285

Description:

PD0166285, with the CAS number 185039-89-8, is a chemical compound that has garnered interest in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized as a small molecule with a specific structure that allows it to interact with biological targets, often related to the modulation of signaling pathways. The compound is typically evaluated for its pharmacological properties, including its efficacy, selectivity, and safety profile in various biological assays. PD0166285 may exhibit properties such as solubility in organic solvents, stability under physiological conditions, and the ability to penetrate cellular membranes, which are crucial for its function as a drug candidate. Additionally, its synthesis involves standard organic chemistry techniques, and it may be analyzed using methods like NMR, mass spectrometry, and chromatography to confirm its identity and purity. Overall, PD0166285 represents a class of compounds that are actively researched for their potential roles in treating specific diseases or conditions.

Formula: C₂₆H₂₇Cl₂N₅O₂

InChI: InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)

InChI key: IFPPYSWJNWHOLQ-UHFFFAOYSA-N

SMILES: CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl

Synonyms:

• Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methyl-
• PD 0166285;PD-0166285
• PD0166285
• 6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

PD0166285

CAS: 185039-89-8

PD0166285

Formula: C₂₆H₂₇Cl₂N₅O₂

Purity: ≥98%

Molecular weight: 512.43

Ref: 54-BUP12226

6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

CAS: 185039-89-8

Formula: C₂₆H₂₇Cl₂N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 512.4309

Ref: IN-DA00ANSP

PD0166285

CAS: 185039-89-8

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.

Formula: C₂₆H₂₇Cl₂N₅O₂

Purity: 99.23%

Color and Shape: Yellow Solid

Molecular weight: 512.431

Ref: TM-T6931

PD0166285

CAS: 185039-89-8

6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Formula: C₂₆H₂₇Cl₂N₅O₂

Purity: 98%

Molecular weight: 512.43

Ref: IN-DG764868

PD0166285

CAS: 185039-89-8

Purity: 98%

Molecular weight: 511.154

Ref: 10-F863360

PD 0166285

Controlled Product

CAS: 185039-89-8

PD 0166285 is an inhibitor of kinase activity. It binds to ATP-binding sites on the epidermal growth factor receptor (EGFR), preventing binding of the ligand and inhibiting downstream signaling pathways. PD 0166285 has been shown to inhibit the proliferation of human HL60 cells and skin cancer cells in culture. This drug also inhibits hyperproliferative diseases, including skin cancer, breast cancer, and lung cancer. PD 0166285 induces apoptosis through activation of caspases 3 and 7, which are key enzymes involved in programmed cell death. In addition, it inhibits angiogenesis by blocking the production of vascular endothelial growth factor (VEGF) from vascular endothelial cells that line blood vessels. PD 0166285 also blocks urothelial carcinoma progression by inducing apoptosis in these cells.

Formula: C₂₆H₂₇Cl₂N₅O₂

Purity: Min. 95%

Molecular weight: 512.43 g/mol

Ref: 3D-KHA03989