CAS 1871-22-3

Blue tetrazolium

Description:

Blue tetrazolium, also known as 2,3,5-Triphenyltetrazolium chloride (TTC), is a chemical compound commonly used in biological and biochemical applications, particularly in cell viability assays. It is a redox indicator that undergoes a color change upon reduction, converting from a yellow soluble form to a red insoluble formazan product in the presence of viable cells. This property makes it useful for assessing metabolic activity in living organisms, as only metabolically active cells can reduce the tetrazolium salt. Blue tetrazolium is typically used in microbiology, histology, and various research applications to evaluate cell proliferation and cytotoxicity. The compound is generally stable under standard laboratory conditions but should be handled with care, as it can be toxic in certain concentrations. Its solubility in water and organic solvents allows for versatile applications in different experimental setups. Overall, blue tetrazolium serves as a valuable tool in the study of cellular processes and the assessment of cell health.

Formula: C₄₀H₃₂N₈O₂·2Cl

InChI: InChI=1S/C40H32N8O2.2ClH/c1-49-37-27-31(23-25-35(37)47-43-39(29-15-7-3-8-16-29)41-45(47)33-19-11-5-12-20-33)32-24-26-36(38(28-32)50-2)48-44-40(30-17-9-4-10-18-30)42-46(48)34-21-13-6-14-22-34;;/h3-28H,1-2H3;2*1H/q+2;;/p-2

InChI key: InChIKey=MUUHXGOJWVMBDY-UHFFFAOYSA-L

SMILES: O(C)C1=C(N2[N+](=NC(=N2)C3=CC=CC=C3)C4=CC=CC=C4)C=CC(=C1)C5=CC(OC)=C(C=C5)N6[N+](=NC(=N6)C7=CC=CC=C7)C8=CC=CC=C8.[Cl-]

Synonyms:

• 2,2′,5,5′-Tetraphenyl-3,3′-(3,3′-dimethoxy-4,4′-diphenylene)ditetrazolium chloride
• 2,2′-(m,m′-Dimethoxy-p,p′-biphenylene)bis(3,5-diphenyltetrazolium chloride)
• 2H-Tetrazolium, 2,2′-(3,3′-dimethoxy[1,1′-biphenyl]-4,4′-diyl)bis[3,5-diphenyl-, chloride (1:2)
• 2H-Tetrazolium, 2,2′-(3,3′-dimethoxy[1,1′-biphenyl]-4,4′-diyl)bis[3,5-diphenyl-, dichloride
• 2H-Tetrazolium, 3,3′-(3,3′-dimethoxy-4,4′-biphenylylene)bis[2,5-diphenyl-, dichloride
• 3,3-(3,3-Dimethoxy-4,4-biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride)
• 3,3′-(3,3′-Dimethoxy-4,4′-biphenylylene)bis[2,5-diphenyl-2H-tetrazolium chloride]
• 3,3′-Dianisolebis[4,4′-(3,5-diphenyl)tetrazolium chloride]
• BT (dye)
• BTC
• Blue Tetrazolium chloride
• Ditetrazolium chloride
• NSC 27623
• Tetrazole blue
• Tetrazolium Blue BT
• Tetrazolium Blue Chloride
• Tetrazolium blue

Blue Tetrazolium [for Biochemical Research]

CAS: 1871-22-3

Formula: C₄₀H₃₂Cl₂N₈O₂

Purity: >95.0%(T)

Color and Shape: White to Amber powder to crystal

Molecular weight: 727.65

Ref: 3B-B3581

Blue Tetrazolium

CAS: 1871-22-3

Formula: C₄₀H₃₂Cl₂N₈O₂

Purity: >95.0%(T)

Color and Shape: White to Amber powder to crystal

Molecular weight: 727.65

Ref: 3B-D0943

Blue Tetrazolium chloride

CAS: 1871-22-3

Blue Tetrazolium chloride is useful in the prepartion of DNA cation complexes and immunoadsorbents for anti-DNA antibodies. It is used in assay of reducing sugars. In combination with 4-nitrocatechol, tetrazolium blue chloride forms a ternary complex with molybdenum(VI) for extraction and spectropho

Formula: C₄₀H₃₆Cl₂N₈O₂

Color and Shape: Pale yellow to yellow, Powder

Molecular weight: 731.68

Ref: 02-A12502

3,3'-(3,3'-DIMETHOXY-[1,1'-BIPHENYL]-4,4'-DIYL)BIS(2,5-DIPHENYL-2H-TETRAZOL-3-IUM) CHLORIDE

CAS: 1871-22-3

Formula: C₄₀H₃₂Cl₂N₈O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 727.6405

Ref: IN-DA007S1S

3,3'-Dianisole-4,4'-bis(3,5-diphenyltetrazolium chloride

CAS: 1871-22-3

3,3'-Dianisole-4,4'-bis(3,5-diphenyltetrazolium chloride

Formula: C₄₀H₃₂N₈O₂·2Cl

Purity: By hplc: 98% (Typical Value in Batch COA)

Color and Shape: Pale yellow Solid-Powder

Molecular weight: 727.64048

Ref: 54-BIT3025

Tetrazolium Blue Chloride

CAS: 1871-22-3

Formula: C₄₀H₃₂Cl₂N₈O₂

Purity: (HPLC) ≥ 95.0%

Color and Shape: Yellow powder

Molecular weight: 727.66

Ref: 7W-GT7170

Tetrazolium blue chloride

CAS: 1871-22-3

Tetrazolium blue chloride is a chemical compound that is used in the diagnosis of leukemia. It is a tetrazolium salt that reacts with reduced nicotinamide adenine dinucleotide (NADH) and produces an insoluble blue product. Tetrazolium blue chloride has been shown to be effective in treating human leukemic cells by causing DNA damage, which leads to cell death. Tetrazolium blue chloride has also been found to be an anti-inflammatory agent due to its ability to inhibit prostaglandin synthesis and production of reactive oxygen species.

Formula: C₄₀H₃₂N₈O₂·2Cl

Purity: 90 To 110%

Color and Shape: Yellow Powder

Molecular weight: 727.64 g/mol

Ref: 3D-ET11162

Blue Tetrazolium Chloride (BTC, Tetrazolium Blue Chloride) extrapure AR

CAS: 1871-22-3

Formula: C₄₀H₃₂O₂N₈Cl₂

Color and Shape: Lemon yellow, Crystalline powder, Clear, Yellow

Molecular weight: 727.66

Ref: SR-22649

Tetrazolium Blue Chloride (>90%)

Controlled Product

CAS: 1871-22-3

Stability Light Sensitive
Applications Tetrazolium Blue Chloride is used for its anti-plasmodium activity. Also used in the study of inhibition of diphenyltetrazolium bromide (MTT) reduction by β-amyloid peptides resulting in neurodegenerative manifestations. Dyes and metabolites.
References Cui, X. et al.: Bioorg, Med. Chem., 16, 1927 (2008); Shearman, M. et al.: J. Neurochem, 65, 218 (1995);

Formula: C₄₀H₃₂N₈O₂·2Cl

Purity: >90%

Color and Shape: Neat

Molecular weight: 727.6

Ref: TR-T310700