CAS 187665-65-2

(1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide

Description:

The chemical substance with the name "(1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide" and CAS number "187665-65-2" is a complex organic compound characterized by its multi-functional structure. It features a benzopyran core, which is a fused ring system containing both benzene and pyran, contributing to its potential biological activity. The presence of a piperazine moiety suggests possible interactions with neurotransmitter receptors, making it of interest in pharmacological research. The aminocarbonyl group indicates the presence of an amide functional group, which can influence solubility and reactivity. This compound is likely to exhibit specific stereochemistry, as indicated by the (1S) configuration, which can affect its biological interactions and efficacy. Overall, this substance may have applications in medicinal chemistry, particularly in the development of therapeutic agents targeting neurological or psychiatric conditions, although specific biological activities would require empirical investigation.

Formula: C₂₄H₃₀N₄O₃

InChI: InChI=1S/C24H30N4O3/c1-26-24(30)19-4-7-21-18(16-19)9-15-31-22(21)8-10-27-11-13-28(14-12-27)20-5-2-17(3-6-20)23(25)29/h2-7,16,22H,8-15H2,1H3,(H2,25,29)(H,26,30)/t22-/m0/s1

InChI key: InChIKey=PNTVCCRNJOGKGA-QFIPXVFZSA-N

SMILES: C(CN1CCN(CC1)C2=CC=C(C(N)=O)C=C2)[C@H]3C=4C(=CC(C(NC)=O)=CC4)CCO3

Synonyms:

• 1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (1S)-
• 1H-2-Benzopyran-6-carboxamide, 1-[2-[4-[4-(aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-, (S)-
• Pnu 142633
• Pnu 3
• Pnu142633
• (1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide

PNU 142633

CAS: 187665-65-2

PNU 142633 is a 5-HT receptor agonist that has been shown to lower blood pressure in animal models. It also has anti-viral properties, and is effective against influenza A virus. PNU 142633 is a 5-HT1A receptor agonist, which may be the cause of its anti-migraine effects. This drug does not bind to the 5-HT2 receptor, which may account for its lack of side effects. The terminal half-life of PNU 142633 is 3 hours in rats; this suggests that it could be used as an antimigraine drug with a long duration of action.

Formula: C₂₄H₃₀N₄O₃

Purity: Min. 95%

Molecular weight: 422.53 g/mol

Ref: 3D-MHA66565

PNU-142633

CAS: 187665-65-2

PNU-142633: anti-migraine, selective 5-HT1D agonist, Ki=6 nM; >18,000 nM for 5-HT1B.

Formula: C₂₄H₃₀N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 422.52

Ref: TM-T16556