CAS 188062-50-2

Abacavir sulfate

Description:

Abacavir sulfate is an antiretroviral medication primarily used in the treatment of HIV infection. It is a nucleoside reverse transcriptase inhibitor (NRTI) that works by interfering with the viral replication process. The compound is characterized by its chemical structure, which includes a bicyclic core and a sulfate moiety, contributing to its pharmacological properties. Abacavir is known for its oral bioavailability and is often administered in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. It is important to note that abacavir can cause hypersensitivity reactions in some individuals, necessitating genetic testing for the HLA-B*5701 allele prior to initiation of therapy. The substance is typically supplied as a sulfate salt to improve solubility and stability. In terms of physical properties, abacavir sulfate is a white to off-white powder, and it is soluble in water, making it suitable for formulation in various dosage forms. Overall, abacavir sulfate plays a crucial role in modern HIV treatment regimens.

Formula: C₁₄H₁₈N₆OH₂O₄S

InChI: InChI=1S/C14H18N6O.H2O4S/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t8-,10+;/m1./s1

InChI key: InChIKey=MBFKCGGQTYQTLR-SCYNACPDSA-N

SMILES: N(C1=C2C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)=NC(N)=N1)C4CC4.S(=O)(=O)(O)O

Synonyms:

• (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate
• 1592U89 sulfate
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-, sulfate (2:1)
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-, sulfate (2:1) (salt)
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S-cis)-, sulfate (2:1) (salt)
• ABC sulfate
• Abacavir Sulfale
• Abacavir hemisulfate
• Abacavir sulphate
• Abamune
• Abavir
• Drg 0257
• Ziagen

ABACAVIR SULFATE FOR SYSTEM SUITABILITY RS

CAS: 188062-50-2

ABACAVIR SULFATE FOR SYSTEM SUITABILITY RS

Formula: C₁₄H₂₀N₆O₅S

Color and Shape: Powder

Molecular weight: 384.4108

Ref: 41-ICRS1552

ABACAVIR SULFATE CRS

CAS: 188062-50-2

ABACAVIR SULFATE CRS

Formula: C₁₄H₂₀N₆O₅S

Color and Shape: Powder

Molecular weight: 384.4108

Ref: 41-Y0001561

Abacavir sulfate

CAS: 188062-50-2

Abacavir sulfate

Formula: C₂₈H₃₈N₁₂O₆S

Purity: 99.7%

Color and Shape: Off White

Molecular weight: 670.2758

Ref: 47-1112

Abacavir impurity standard

CAS: 188062-50-2

Abacavir impurity standard

Color and Shape: Off-White

Ref: 47-1113

ABACAVIR FOR SYSTEM SUITABILITY CRS

CAS: 188062-50-2

ABACAVIR FOR SYSTEM SUITABILITY CRS

Formula: C₁₄H₂₀N₆O₅S

Color and Shape: Powder

Molecular weight: 384.4108

Ref: 41-Y0001551

ABACAVIR SULFATE RS

CAS: 188062-50-2

ABACAVIR SULFATE RS

Formula: C₁₄H₂₀N₆O₅S

Color and Shape: Powder

Molecular weight: 384.4108

Ref: 41-ICRS1422

ABACAVIR FOR PEAK IDENTIFICATION CRS

CAS: 188062-50-2

ABACAVIR FOR PEAK IDENTIFICATION CRS

Formula: C₁₄H₂₀N₆O₅S

Color and Shape: Powder

Molecular weight: 384.4108

Ref: 41-Y0001552

Abacavir Sulfate Racemic (4-[2-amino-6-(cyclopropylamino)-9H-purin-9yl]-2-cyclopentene-1-methanol sulfate (2:1))

CAS: 188062-50-2

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, nesoi

Formula: (C₁₄H₁₈N₆O)₂·H₂SO₄

Color and Shape: Off-White Powder

Molecular weight: 670.2758

Ref: 45-1000419

Abacavir Sulfate

CAS: 188062-50-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: (C₁₄H₁₈N₆O)₂·H₂SO₄

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 670.2758

Ref: 45-1000408

2-CYCLOPENTENE-1-METHANOL, 4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURIN-9-YL]-, (1S,4R)-, SULFATE (2:1)

CAS: 188062-50-2

Formula: C₁₄H₂₀N₆O₅S

Purity: 99%

Color and Shape: Solid

Molecular weight: 384.4108

Ref: IN-DA002GOO

Abacavir sulfate

CAS: 188062-50-2

Formula: C₁₄H₁₈N₆O·5(H₂SO₄)

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 335.37

Ref: 7W-GP9949

((1S,4R)-4-(2-Amino-6-(Cyclopropylamino)-9H-Purin-9-yl)Cyclopent-2-en-1-yl)Methanol Hemisulfate

CAS: 188062-50-2

((1S,4R)-4-(2-Amino-6-(Cyclopropylamino)-9H-Purin-9-yl)Cyclopent-2-en-1-yl)Methanol Hemisulfate

Purity: 98%

Molecular weight: 670.74g/mol

Ref: 54-OR1007767

Abacavir sulfate

CAS: 188062-50-2

Abacavir sulfate

Purity: ≥98%

Molecular weight: 335.38g/mol

Ref: 54-BUP15741

Abacavir Sulfate

CAS: 188062-50-2

Formula: C₂₈H₃₆N₁₂O₂·H₂O₄S

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 670.75

Ref: 3B-A3532

Abacavir Sulfate

Controlled Product

CAS: 188062-50-2

Formula: C₁₄H₁₈N₆O·H₂O₄S

Color and Shape: Neat

Molecular weight: 670.74

Ref: 86-MM3249.00

Abacavir sulfate

CAS: 188062-50-2

Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity

Formula: C₁₄H₁₈N₆OH₂O₄S

Purity: 99.79% - 99.85%

Color and Shape: White To Off-White Solid

Molecular weight: 335.38

Ref: TM-T6367

Abacavir sulfate

Controlled Product

CAS: 188062-50-2

Impurity Abacavir - In House Impurity
Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₁₈N₆O·H₂O₄S

Color and Shape: Off White

Molecular weight: 670.74

Ref: TR-A105000

Abacavir sulfate

CAS: 188062-50-2

Anti-viral; reverse transcriptase inhibitor

Formula: C₁₄H₁₈N₆OH₂SO₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 670.75 g/mol

Ref: 3D-NA10019

Abacavir sulfate - Bio-X ™

CAS: 188062-50-2

Abacavir sulfate is an antiviral drug that belongs to the class of HIV protease inhibitors. It is used in combination with other antiretroviral drugs to treat HIV-1 infection. Abacavir sulfate inhibits viral replication by blocking the activity of HIV-1 protease, which is necessary for the production of new virus particles.
Abacavir sulfate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₄H₁₈N₆OH₂SO₄

Purity: Min. 98 Area-%

Color and Shape: Solid

Molecular weight: 670.75 g/mol

Ref: 3D-BA165908

rac-Abacavir Sulfate

Controlled Product

CAS: 136470-79-6, 188062-50-2

Formula: C₁₄H₁₈N₆O·H₂SO₄

Color and Shape: Neat

Molecular weight: 670.743

Ref: TR-A105025