CAS 1884269-07-1

Sacubitril-d4

CAS: 1884269-07-1

Formula: C₂₄H₂₅D₄NO₅

Color and Shape: Colorless Oil

Molecular weight: 415.52

Ref: 4Z-S-072009

Sacubitril-d4

Controlled Product

CAS: 1884269-07-1

Applications Isotope labelled Sacubitril is an antihypertensive drug used in combination with Valsartan (V095750). The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Formula: C₂₄₂H₄H₂₅NO₅

Color and Shape: Light Yellow

Molecular weight: 415.52

Ref: TR-S080897

Sacubitril-d4

CAS: 1884269-07-1

Sacubitril-d4 is a new drug candidate that has been shown to be a potent inhibitor of the angiotensin converting enzyme (ACE). It is a prodrug that can be hydrolyzed to sacubitril, which inhibits the conversion of angiotensin I (ATI) to ATII. Sacubitril-d4 was found to inhibit the production of ATP in healthy Chinese subjects and in plasma samples from patients with heart failure. The compound also demonstrated high specificity for ACE, as it did not show any significant activity against other enzymes. This study also showed that sacubitril-d4 could be detected using a mass spectrometer equipped with an electrospray ionization source, which may make this drug more suitable for clinical use.

Formula: C₂₄H₂₉NO₅

Purity: Min. 95%

Molecular weight: 415.5 g/mol

Ref: 3D-JAD26907

Sacubitril-D4

CAS: 1884269-07-1

Formula: C₂₄H₂₅D₄NO₅

Molecular weight: 415.5

Ref: ST-EA-CP-S18079