CAS 188844-34-0

4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

Description:

The chemical substance known as 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid, with the CAS number 188844-34-0, is a complex organic compound characterized by its intricate molecular structure, which includes multiple fused ring systems and functional groups. This compound features a benzoic acid moiety, indicating the presence of a carboxylic acid group, which contributes to its acidic properties. The presence of a nitro group suggests potential reactivity and influence on the compound's electronic properties. The tetrahydro and pentamethyl groups indicate a degree of saturation and steric hindrance, which can affect the compound's solubility and interaction with biological systems. Such compounds may exhibit interesting pharmacological activities, making them of interest in medicinal chemistry. However, specific properties such as solubility, melting point, and biological activity would require empirical data for precise characterization.

Formula: C₂₉H₂₉N₃O₄

InChI: InChI=1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34)

InChI key: InChIKey=SXKPGYKPQPYJER-UHFFFAOYSA-N

SMILES: CN1C=2C(C(=NC=3C1=CC=C(N(=O)=O)C3)C4=CC=C(C(O)=O)C=C4)=CC5=C(C2)C(C)(C)CCC5(C)C

Synonyms:

• HX 531
• 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid
• Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-

HX 531

CAS: 188844-34-0

Formula: C₂₉H₂₉N₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 483.5583

Ref: IN-DA00AKRS

HX 531

CAS: 188844-34-0

HX 531

Purity: ≥98%

Molecular weight: 483.56g/mol

Ref: 54-BUP06788

HX 531

CAS: 188844-34-0

HX 531 is a RXR antagonist (IC50 of 18 nM).Cost-effective and quality-assured.

Formula: C₂₉H₂₉N₃O₄

Purity: 98.59% - 99.86%

Color and Shape: Solid

Molecular weight: 483.56

Ref: TM-T22843

HX 531

Controlled Product

CAS: 188844-34-0

Applications HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.
References Yamauchi, T. et al.: J. Clin. Invest., 108, 1001 (2001);

Formula: C₂₉H₂₉N₃O₄

Color and Shape: Neat

Molecular weight: 483.56

Ref: TR-H674253

HX 531

Controlled Product

CAS: 188844-34-0

HX 531 is a synthetic retinoid that is used to treat cancer. The drug binds to the ATP-binding cassette transporter and inhibits its function, which leads to an increase in energy metabolism. HX 531 has been shown to be effective in treating inflammatory bowel disease by reducing the production of cytokines, such as IL-1β and TNF-α. The drug has also shown activity against tumor cells, as well as other diseases that are caused by oxidative injury. HX 531 has pharmacokinetic properties that allow it to pass through the mitochondrial membrane potential without being degraded by cytochrome P450 enzymes and is metabolized by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid.

Formula: C₂₉H₂₉N₃O₄

Purity: Min. 95%

Molecular weight: 483.56 g/mol

Ref: 3D-NHA84434