CAS 19186-35-7

(5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

Description:

The chemical substance with the name "(5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one" and CAS number "19186-35-7" is a complex organic compound characterized by its intricate polycyclic structure, which includes a naphthalene core fused with a dioxole and a tetrahydrofuran moiety. This compound features multiple methoxy groups, which are known to enhance solubility and influence biological activity. The stereochemistry indicated by the R configurations suggests specific spatial arrangements that can significantly affect the compound's reactivity and interactions with biological targets. Such compounds often exhibit interesting pharmacological properties, making them subjects of interest in medicinal chemistry. Additionally, the presence of multiple functional groups can lead to diverse chemical reactivity, allowing for potential modifications that could enhance therapeutic efficacy or reduce toxicity. Overall, this compound exemplifies the complexity and diversity found in organic chemistry, particularly in the realm of natural product synthesis and drug development.

Formula: C₂₂H₂₂O₇

InChI: InChI=1/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1

InChI key: InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Synonyms:

• (-)-Anthricin
• (5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4-Deoxypodophyllotoxin
• As 2-3
• Deoxypodophyllotoxin
• Desoxypodophyllotoxin
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα)]-
• Podophyllotoxin, deoxy-
• Silicicolin
• Anthricin/Deoxypodophyllotoxin
• anthric
• Podophyllotoxin 9-Desoxy Impurity
• Deoxypodophyllotoxin, deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 398.4059

Ref: IN-DA002FHT

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin

Purity: ≥98%

Molecular weight: 398.41g/mol

Ref: 54-BUP16322

Deoxypodophyllotoxin

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Molecular weight: 398.41

Ref: 7W-GY9442

Podophyllotoxin Impurity 5

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Color and Shape: White To Off-White Solid

Molecular weight: 398.41

Ref: 4Z-P-122005

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Formula: C₂₂H₂₂O₇

Purity: 95%~99%

Molecular weight: 398.41

Ref: BP-SBP02032

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.

Formula: C₂₂H₂₂O₇

Purity: 99.65% - 99.84%

Color and Shape: Solid

Molecular weight: 398.41

Ref: TM-TN1087

4-Deoxypodophyllotoxin

CAS: 19186-35-7

4-Deoxypodophyllotoxin is a natural lignan, which is a type of secondary metabolite. It is primarily sourced from the roots and rhizomes of several plants belonging to the Podophyllum species, such as Podophyllum hexandrum. This compound exhibits its mode of action by interfering with microtubule assembly, thus disrupting cell division and leading to apoptotic cell death. Its effectiveness at halting mitosis makes it a subject of interest in cancer research.

Formula: C₂₂H₂₂O₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 398.41 g/mol

Ref: 3D-FD157413

4-Deoxypodophyllotoxin

Controlled Product

CAS: 19186-35-7

Applications 4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, C.X., et al.: Planta. Med., 70, 474 (2004); Peng, Xu., et al.: Neurotoxicol., 31, 680 (2010); Kim, Y., et al.: Planta, Med., 68, 271 (2002);

Formula: C₂₂H₂₂O₇

Color and Shape: Off-White

Molecular weight: 398.41

Ref: TR-D249500