CAS 1936422-33-1

Formula: C27H33F2N7O2

InChI: InChI=1S/C27H33F2N7O2/c1-30-27(37)34-9-5-23-22(16-34)26(32-36(23)19-6-10-38-11-7-19)35-8-3-4-17-12-20(18-14-31-33(2)15-18)21(25(28)29)13-24(17)35/h12-15,19,25H,3-11,16H2,1-2H3,(H,30,37)

InChI key: CQCWHSDMJBAGDC-UHFFFAOYSA-N

SMILES: CNC(=O)N1CCC2=C(C1)C(=NN2C3CCOCC3)N4CCCC5=CC(=C(C=C54)C(F)F)C6=CN(N=C6)C

GNE-781

CAS: 1936422-33-1

GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).

Formula: C₂₇H₃₃F₂N₇O₂

Purity: 99.25% - 99.64%

Color and Shape: Solid

Molecular weight: 525.59

Ref: TM-T15405

3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

CAS: 1936422-33-1

Purity: 99%

Ref: IN-DA01E3KF

GNE-781

CAS: 1936422-33-1

GNE-781

Formula: C₂₇H₃₃F₂N₇O₂

Purity: ≥98%

Molecular weight: 525.59

Ref: 54-BUP04443

GNE-781

CAS: 1936422-33-1

3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

Formula: C₂₇H₃₃F₂N₇O₂

Purity: 99%

Molecular weight: 525.59

Ref: IN-DG01115810

GNE-781

Controlled Product

CAS: 1936422-33-1

Formula: C₄H₁₁NO·HCl

Color and Shape: Neat

Molecular weight: 125.597

Ref: TR-D447825

GNE 781

CAS: 1936422-33-1

A selective inhibitor of the bromodomain of Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREBBP or CBP) with anti-tumoral activity. The CBP inhibition regulates oncogene MYC and impairs differentiation of regulatory T cells.

Formula: C₂₇H₃₃F₂N₇O₂

Purity: Min. 95%

Molecular weight: 525.59 g/mol

Ref: 3D-BG166815