CAS 1951-25-3

Amiodarone

Description:

Amiodarone is a complex organic compound primarily used as an antiarrhythmic medication to treat various types of cardiac dysrhythmias. Its chemical formula is C25H29I2N, indicating that it contains carbon, hydrogen, iodine, and nitrogen atoms. Amiodarone is characterized by its lipophilic nature, which allows it to accumulate in various tissues, particularly in the lungs, liver, and thyroid. The substance exhibits a long half-life, leading to prolonged effects even after discontinuation of therapy. It functions by inhibiting adrenergic stimulation, prolonging the myocardial action potential, and affecting ion channels, which helps stabilize heart rhythms. Amiodarone is also known for its potential side effects, including thyroid dysfunction, pulmonary toxicity, and skin changes, necessitating careful monitoring during treatment. Its solubility in organic solvents and limited solubility in water are notable physical properties, influencing its formulation and administration routes. Overall, amiodarone is a vital medication in cardiology, but its use requires a thorough understanding of its pharmacokinetics and potential adverse effects.

Formula: C₂₅H₂₉I₂NO₃

InChI: InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3

InChI key: InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3

Synonyms:

• (2-Butyl-1-Benzofuran-3-Yl){4-[2-(Diethylamino)Ethoxy]-3,5-Diiodophenyl}Methanone
• (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone
• 2-Butyl-3-[3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl]benzofuran
• 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone
• 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
• 2-n-Butyl-3′,5′-diiodo-4′-N-diethylaminoethoxy-3-benzoylbenzofuran
• 2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}-N,N-diethylethanaminium chloride
• Amidorone
• Amiodaron
• Amiodarona
• Amiodarone Base
• Ancaron
• Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl
• Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-
• Sedacoron
• Sedacorone
• Amiodarone

Amiodarone Hydrochloride

CAS: 1951-25-3, 19774-82-4

Formula: C₂₅H₂₉I₂NO₃·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 681.78

Ref: 3B-A2530

{2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine

CAS: 1951-25-3

Formula: C₂₅H₂₉I₂NO₃

Purity: 98%

Color and Shape: Liquid

Molecular weight: 645.3116

Ref: IN-DA007RDP

Amiodarone

CAS: 1951-25-3

Formula: C₂₅H₂₉I₂NO₃

Purity: ≥ 96.0%

Color and Shape: Colourless to pale yellow oil or solid

Molecular weight: 645.31

Ref: 7W-GP2653

Amiodarone

CAS: 1951-25-3

Amiodarone

Purity: ≥98%

Molecular weight: 645.31g/mol

Ref: 54-BUP02367

Amiodarone

CAS: 1951-25-3

Applications Amiodarone is a non-selective ion channel blocker. Antiarrhythmic (class III).
References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984); Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991); Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)

Formula: C₂₅H₂₉I₂NO₃

Color and Shape: Colourless To Light Yellow

Molecular weight: 645.31

Ref: TR-A632945

Amiodarone

CAS: 1951-25-3

Amiodarone (Cordarone) is an antiarrhythmic compound that induces pulmonary toxicity and inhibits ATP-sensitive potassium channels.

Formula: C₂₅H₂₉I₂NO₃

Purity: 98.09%

Color and Shape: Crystalline Powder; Crystals From Acetone Solid

Molecular weight: 645.31

Ref: TM-T21370

Amiodarone

Controlled Product

CAS: 1951-25-3

Amiodarone is a drug that is used to treat and prevent certain types of irregular heartbeats. It belongs to the group of drugs called class III anti-arrhythmics. Amiodarone is a long-acting medication that can take up to three weeks for full effect. Amiodarone has been shown to reduce the number of atrial and ventricular arrhythmias in patients with structural heart disease. This drug also has significant cytotoxicity, which means it may affect normal cells as well as cancer cells, and increases the risk of serious side effects such as fibrillation and glucose intolerance. Amiodarone should not be taken with other medications that can cause fibrillation or make it hard for your body to control blood pressure, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.

Formula: C₂₅H₂₉I₂NO₃

Purity: Min. 95%

Molecular weight: 645.31 g/mol

Ref: 3D-BAA95125