CAS 19542-67-7

(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

Description:

(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile, with the CAS number 19542-67-7, is an organic compound characterized by its unique functional groups and structural features. It contains a propenenitrile backbone, which is a conjugated system featuring a double bond and a nitrile group (-C≡N). The presence of a sulfonyl group (-SO2-) attached to a para-methylphenyl moiety enhances its reactivity and solubility in various organic solvents. This compound is typically a solid at room temperature and may exhibit moderate to high stability under standard conditions. Its chemical properties are influenced by the electron-withdrawing nature of the nitrile and sulfonyl groups, which can affect its reactivity in nucleophilic addition reactions. Additionally, the compound may have applications in organic synthesis and materials science due to its potential as a building block for more complex molecules. Safety data should be consulted for handling, as sulfonyl compounds can sometimes pose health risks.

Formula: C₁₀H₉NO₂S

InChI: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

InChI key: InChIKey=DOEWDSDBFRHVAP-KRXBUXKQSA-N

SMILES: S(/C=C/C#N)(=O)(=O)C1=CC=C(C)C=C1

Synonyms:

• (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
• (2E)-3-[(4-Methylphenyl)sulfonyl]acrylonitrile
• (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
• 2-Propenenitrile, 3-((4-methylphenyl)sulfonyl)-
• 2-Propenenitrile, 3-[(4-methylphenyl)sulfonyl]-, (2E)-
• 2-Propenenitrile, 3-[(4-methylphenyl)sulfonyl]-, (E)-
• 3-((4-Methylphenyl)sulfonyl)-2-propenenitrile
• 3-(p-Toluenesulfonyl)acrylonitrile
• 3-(p-Tolylsulfonyl)acrylonitrile
• Acrylonitrile, 3-(p-tolylsulfonyl)-, (E)-
• Bay 11-7082
• Bay 11-7821

BAY 11-7082

CAS: 19542-67-7

Formula: C₁₀H₉NO₂S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 207.25

Ref: 3B-T2846

BAY 11-7082

CAS: 19542-67-7

BAY 11-7082

Formula: C₁₀H₉NO₂S

Purity: ≥95%

Molecular weight: 207.25

Ref: 54-BUP15546

BAY 11-7082

CAS: 19542-67-7

BAY 11-7082

Formula: C₁₀H₉NO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 207.24895

Ref: 54-BISN0126

BAY 11-7082

CAS: 19542-67-7

Formula: C₁₀H₉NO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 207.2490

Ref: IN-DA003C0J

BAY 11-7082

Controlled Product

CAS: 19542-67-7

Applications BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of Iκβα without affecting constitutive Iκβα phosphorylation. Potent IKK inhibitor
References Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)

Formula: C₁₀H₉NO₂S

Color and Shape: Neat

Molecular weight: 207.25

Ref: TR-B118790

BAY 11-7082

CAS: 19542-67-7

(E)-3-Tosylacrylonitrile

Formula: C₁₀H₉NO₂S

Purity: 98%

Molecular weight: 207.25

Ref: IN-DG242525

BAY 11-7082

CAS: 19542-67-7

BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).

Formula: C₁₀H₉NO₂S

Purity: 98% - 99.96%

Color and Shape: Solid

Molecular weight: 207.25

Ref: TM-T1902

Bay 11-7082

CAS: 19542-67-7

Formula: C₁₀H₉NO₂S

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 207.25

Ref: 7W-GK8638

(E)-3-Tosylacrylonitrile

CAS: 19542-67-7

Formula: C₁₀H₉NO₂S

Purity: 98%

Molecular weight: 207.25

Ref: 10-F324320