CAS 19545-26-7: WORTMANNIN

Description:Wortmannin is a natural product and a potent inhibitor of phosphoinositide 3-kinases (PI3Ks), which play a crucial role in various cellular processes, including growth, proliferation, and survival. It is derived from the fungus *Penicillium wortmannii* and is characterized by its complex molecular structure, which includes a lactone ring and a unique epoxide group. Wortmannin exhibits a high degree of specificity for PI3K isoforms, making it a valuable tool in biochemical research for studying signaling pathways. Its mechanism of action involves the covalent modification of the enzyme, leading to the inhibition of downstream signaling cascades. Additionally, wortmannin has been investigated for its potential therapeutic applications, particularly in cancer treatment, due to its ability to induce apoptosis in certain cancer cell lines. However, its use is limited by its instability in aqueous solutions and potential off-target effects. Overall, wortmannin serves as an important compound in the study of cellular signaling and therapeutic development.

Formula:C₂₃H₂₄O₈

InChI:InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChI key:InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N

SMILES:O=C1OC(COC)C2(C3=C(OC=C13)C(=O)C4=C2C(OC(=O)C)CC5(C(=O)CCC45)C)C

Synonyms:
(1R,6bS,9aR,11S,11bS)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
(1S,6Br,9As,11R,11Br) 11-(Acetyloxy)-1,6B,7,8,9A,10,11,11B-Octahydro-1-(Methoxymethyl)-9A,11B-Dimethyl-3H-Furo[4,3,2-De]Indeno[[4,5-H]-2-H]-2-Benzopyran-3,6,9-Trione
(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
(1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
(1S,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, [1S-(1α,6bα,9aβ,11α,11bβ)]-
Antibioticsl-2052
Ky 12420
See more synonyms
Pi 3-Kinase Inhibitor
Sl-2052
Wortmannin, Penicillium Wortmanni
[1S-(1Alpha,6Balpha,9Abeta,11Alpha,11Bbeta)]-11-(Acetyloxy)-1,6B,7,8,9A,10,11,11B-Octahydro-1-(Methoxymethyl)-9A,11B-Dimethyl-3H-Furo[4,3,2-De]Indeno[4,5-H]-2-Benzopyran-3,6,9-Trione

Found 8 products.

Product data	Purity	Price range	Estimated delivery
Wortmannin REF: 3B-W0007CAS: 19545-26-7	>98.0%(HPLC)	84.00 €	Fri 04 Apr 25
Wortmannin; SL-2052 REF: 8R-JU0027CAS: 19545-26-7	89.99%	To inquire	Mon 07 Apr 25
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)- REF: IN-DA00I3DXCAS: 19545-26-7	98%	To inquire	Fri 11 Apr 25
Wortmannin, from Penicillium funiculosum REF: 54-BIW4201CAS: 19545-26-7	By hplc: >99% (Typical Value in Batch COA)	141.00 €~5,287.00 €	Mon 14 Apr 25
Wortmannin, 98% REF: AC-32859CAS: 19545-26-7	98%	95.00 €~426.00 €	Mon 14 Apr 25
Wortmannin REF: TM-T6283CAS: 19545-26-7	95.84% - 99.76%	48.00 €~512.00 €	Mon 21 Apr 25
Wortmannin REF: 7W-GE4316CAS: 19545-26-7	≥ 99.0%	108.00 €~545.00 €	Mon 21 Apr 25
Wortmannin REF: TR-W499400CAS: 19545-26-7	- - -	101.00 €~856.00 €	Mon 21 Apr 25