CAS 19545-26-7

WORTMANNIN

Description:

Wortmannin is a natural product and a potent inhibitor of phosphoinositide 3-kinases (PI3Ks), which play a crucial role in various cellular processes, including growth, proliferation, and survival. It is derived from the fungus *Penicillium wortmannii* and is characterized by its complex molecular structure, which includes a lactone ring and a unique epoxide group. Wortmannin exhibits a high degree of specificity for PI3K isoforms, making it a valuable tool in biochemical research for studying signaling pathways. Its mechanism of action involves the covalent modification of the enzyme, leading to the inhibition of downstream signaling cascades. Additionally, wortmannin has been investigated for its potential therapeutic applications, particularly in cancer treatment, due to its ability to induce apoptosis in certain cancer cell lines. However, its use is limited by its instability in aqueous solutions and potential off-target effects. Overall, wortmannin serves as an important compound in the study of cellular signaling and therapeutic development.

Formula: C₂₃H₂₄O₈

InChI: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChI key: InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N

SMILES: C[C@@]12C3=C([C@]4([C@](C)(C[C@H]3OC(C)=O)C(=O)CC4)[H])C(=O)C5=C1C(C(=O)O[C@@H]2COC)=CO5

Synonyms:

• (1R,6bS,9aR,11S,11bS)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
• (1S,6Br,9As,11R,11Br) 11-(Acetyloxy)-1,6B,7,8,9A,10,11,11B-Octahydro-1-(Methoxymethyl)-9A,11B-Dimethyl-3H-Furo[4,3,2-De]Indeno[[4,5-H]-2-H]-2-Benzopyran-3,6,9-Trione
• (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
• (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
• (1S,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
• 1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
• 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-
• 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, [1S-(1α,6bα,9aβ,11α,11bβ)]-
• Antibioticsl-2052
• Ky 12420
• Pi 3-Kinase Inhibitor
• Sl-2052
• Wortmannin, Penicillium Wortmanni

Wortmannin

CAS: 19545-26-7

Formula: C₂₃H₂₄O₈

Purity: >98.0%(HPLC)

Color and Shape: White to Yellow powder to crystal

Molecular weight: 428.44

Ref: 3B-W0007

Wortmannin; SL-2052

CAS: 19545-26-7

Formula: C₂₃H₂₄O₈

Purity: 89.99%

Color and Shape: Yellowish. Amorphous solid

Molecular weight: 428.0

Ref: 8R-JU0027

(1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione

CAS: 19545-26-7

Formula: C₂₃H₂₄O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.4319

Ref: IN-DA00I3DX

Wortmannin

CAS: 19545-26-7

Wortmannin

Purity: ≥95%

Molecular weight: 428.43g/mol

Ref: 54-BUP05594

Wortmannin, from Penicillium funiculosum

CAS: 19545-26-7

Wortmannin, from Penicillium funiculosum

Formula: C₂₃H₂₄O₈

Purity: 98%

Color and Shape: white to off-white solid

Molecular weight: 428.43g/mol

Ref: 54-BIW4201

Wortmannin

CAS: 19545-26-7

Formula: C₂₃H₂₄O₈

Purity: ≥ 99.0%

Color and Shape: White to faint yellow powder

Molecular weight: 428.44

Ref: 7W-GE4316

Wortmannin

CAS: 19545-26-7

Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.

Formula: C₂₃H₂₄O₈

Purity: 95.84% - 99.76%

Color and Shape: White Solid

Molecular weight: 428.43

Ref: TM-T6283

Wortmannin

Controlled Product

CAS: 19545-26-7

Applications Wortmannin is a phosphatidylinositol 3 kinase (PI3K) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liberman R., et. al.: J. Biol. Chem., 289, 1355 (2014)

Formula: C₂₃H₂₄O₈

Color and Shape: White To Light Yellow

Molecular weight: 428.43

Ref: TR-W499400

Wortmannin

CAS: 19545-26-7

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Formula: C₂₃H₂₄O₈

Molecular weight: 428.43 g/mol

Ref: 3D-XW176913