CAS 1973494-17-5

Formula: C16H23Cl2N3O2S

InChI: InChI=1S/C16H21N3O2S.2ClH/c1-12(17)13-6-9-19(10-7-13)22(20,21)16-4-2-3-14-11-18-8-5-15(14)16;;/h2-5,8,11-13H,6-7,9-10,17H2,1H3;2*1H/t12-;;/m1../s1

InChI key: ZGHFCJWOBKWTQK-CURYUGHLSA-N

SMILES: C[C@H](C1CCN(CC1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3)N.Cl.Cl

NRL-1049 dihydrochloride

CAS: 1973494-17-5

NRL-1049 dihydrochloride (BA-1049) is an orally active and selective inhibitor of Rho-associated protein kinase 2 (ROCK2) with an IC₅₀ value of 0.59 μM. It demonstrates a 44-fold selectivity for ROCK2 over ROCK1, which has an IC₅₀ value of 26 μM. NRL-1049 dihydrochloride can protect the blood-brain barrier following acute injury.

Formula: C₁₆H₂₃Cl₂N₃O₂S

Molecular weight: 392.34

Ref: TM-T214049