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CAS 1977-10-2

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Loxapine

Description:
Loxapine is an antipsychotic medication primarily used to treat schizophrenia and acute manic episodes associated with bipolar disorder. It belongs to the class of drugs known as dibenzoxazepines, which are structurally related to tricyclic antidepressants. Loxapine functions as a dopamine antagonist, primarily blocking D2 receptors in the brain, which helps to alleviate psychotic symptoms. It also exhibits some affinity for serotonin receptors, contributing to its therapeutic effects. The substance is typically administered orally and can be found in various formulations, including tablets and injectable forms. Loxapine's pharmacokinetics involve extensive hepatic metabolism, and it has a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include sedation, weight gain, and extrapyramidal symptoms, which are typical of many antipsychotic medications. Due to its potential for causing tardive dyskinesia and other movement disorders, careful monitoring is essential during treatment. Overall, loxapine is an important option in the management of certain psychiatric conditions, particularly when other treatments are ineffective.
Formula:C18H18ClN3O
InChI:InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
InChI key:InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(=NC=3C(OC2=CC1)=CC=CC3)N4CCN(C)CC4
Synonyms:
  • 2-Chloro-11-(4-Methylpiperazin-1-Yl)Dibenzo[B,F][1,4]Oxazepine
  • 2-Chloro-11-(4-Methylpiperazin-1-Yl)Dibenzo[B,F][1,4]Oxazepine Butanedioate (1:1)
  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine
  • 2-Chloro-11-(4-methylpiperazino)dibenz[b,f][1,4]oxazepine
  • 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)oxazepine
  • Adasuve
  • Brn 0626753
  • Cl 62362
  • Cloxazepine
  • Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
  • See more synonyms
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Found 5 products.